RGS7 and SDCCAG8

		RGS7	SDCCAG8
Description		regulator of G protein signaling 7	SHH signaling and ciliogenesis regulator SDCCAG8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Presynaptic Membrane Neuron Projection Dendrite Terminus Postsynaptic Membrane Cell Tip Presynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cell-cell Junction Cilium Centriolar Satellite Ciliary Basal Body Cell Projection Anchoring Junction Photoreceptor Cell Cilium
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential	Neuron Migration Centrosome Cycle Establishment Of Cell Polarity Cell Projection Organization Microtubule Organizing Center Organization Tube Formation Regulation Of Cilium Assembly
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 29124443) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 30578418 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31451708 30604766 31015462 31152163) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Mean platelet volume ( 32888494) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Obesity (early onset extreme) ( 20421936) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Schizophrenia ( 30285260 29483656 25056061 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Toenail selenium levels ( 25343990) Walking pace ( 33128006)
Interacting Genes		17 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SDCCAG8 SNAPIN YWHAB YWHAQ	5 interacting genes: AKT3 CEP170 FBXO7 RGS7 TNS2
Entrez ID		6000	10806
HPRD ID		03948	10215
Ensembl ID		ENSG00000182901	ENSG00000054282
Uniprot IDs		A0A8I5KUA7 A0A8I5KXW5 A0A8I5KZ50 A0A8I5QJU0 B7Z257 P49802	Q86SQ7
PDB IDs		2A72 2D9J 7EWP 7EWR 7SHF
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Activity Guanyl Nucleotide Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Regulation Of Protein Transport Dendrite G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Establishment Of Protein Localization GTPase Activity Regulation Of Transport Regulation Of Insulin Secretion G Protein-coupled Receptor Binding Synapse Regulation Of Peptide Hormone Secretion Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Negative Regulation Of Protein Transport Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Ciliary Basal Body Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Regulation Of Protein Localization Saliva Secretion Trans-synaptic Signaling Synaptic Signaling Regulation Of Secretion GTP Binding Negative Regulation Of Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality G Protein Activity	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Dendrite Terminus
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