BCL2L2 and SLC39A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCL2L2	SLC39A2
Description		BCL2 like 2	solute carrier family 39 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Plasma Membrane Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Monoatomic Ion Transport Zinc Ion Transport Metal Ion Transport Keratinocyte Differentiation Transmembrane Transport Cadmium Ion Transmembrane Transport Zinc Ion Transmembrane Transport
Pathways			Zinc influx into cells by the SLC39 gene family
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	55 interacting genes: AQP1 AQP6 ARL13B ARLN BCL2L2 BTN2A2 C3orf52 CD79A CLCA4 CNR2 COL4A5 COMT CREB3L1 CXCR2 CYB561 EHHADH EMC6 FAM209A FCER1G FXYD3 FXYD6 GJA8 GPR152 GPR42 IL6R KCNAB1 KCNAB2 KCNJ15 LY6G6C MFSD6 MS4A13 PLN PNLIPRP1 POR SEC22A SLC18A1 SLC30A2 SLC30A8 SLC39A1 SLC39A9 SLC66A1 SLC7A1 SSMEM1 ST6GAL2 STATH TMEM107 TMEM14B TMEM229B TMEM237 TMEM54 TMEM60 TMEM86A TRHR UPK1B YIPF6
Entrez ID		599	29986
HPRD ID		03569	15385
Ensembl ID		ENSG00000129473	ENSG00000165794
Uniprot IDs		Q92843	Q9NP94
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death	Membrane Transmembrane Transport Monoatomic Ion Transport Zinc Ion Transmembrane Transporter Activity Inorganic Ion Transmembrane Transport Zinc Ion Transport Zinc Ion Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Lysine Transport Potassium Ion Transport Inorganic Cation Transmembrane Transport Protein Binding Plasma Membrane Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Zinc:proton Antiporter Activity Monoamine Transport Intracellular Zinc Ion Homeostasis Monoatomic Cation Transmembrane Transport L-lysine Transmembrane Transport Organic Cation Transport Ion Channel Regulator Activity Renal Water Transport Norepinephrine Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Neural Tube Patterning Channel Activity Ammonium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Ammonium Transmembrane Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Zinc Ion Aromatic Amino Acid Transport Zinc Ion Import Into Organelle L-arginine Transmembrane Transport Transport Vesicle Membrane Serotonin Transport Azole Transmembrane Transport Juxtaparanode Region Of Axon Alcohol Dehydrogenase (NADP+) Activity External Side Of Plasma Membrane Water Channel Activity Carbon Dioxide Transport
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