RELB and BCL7A

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RELB	BCL7A
Description		RELB proto-oncogene, NF-kB subunit	BAF chromatin remodeling complex subunit BCL7A
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Transcription Repressor Complex Protein-containing Complex Synapse NF-kappaB Complex	Chromatin Nucleoplasm SWI/SNF Complex GBAF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Inflammatory Response Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Response To Cytokine Non-canonical NF-kappaB Signal Transduction T-helper 1 Type Immune Response Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Osmotic Stress	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Motor Behavior Regulation Of G0 To G1 Transition Neuron Projection Arborization Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK-->noncanonical NF-kB signaling	Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Red cell distribution width ( 32888494) Triglyceride levels ( 32154731)	A body shape index ( 34021172) Body size at age 10 ( 32376654) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular volume ( 27863252) Mean platelet volume ( 24026423) Mean spheric corpuscular volume ( 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MAP1LC3A MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	4 interacting genes: ALAS1 APPBP2 CD151 RELB
Entrez ID		5971	605
HPRD ID		06886	03243
Ensembl ID		ENSG00000104856	ENSG00000110987
Uniprot IDs		D6R992 Q01201	Q4VC05
PDB IDs		8G8R
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleotide-excision Repair SWI/SNF Complex NBAF Complex Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of Sister Chromatid Segregation NpBAF Complex Regulation Of Stem Cell Population Maintenance Regulation Of Chromosome Segregation RSC-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Remodeling Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Developmental Process Chromatin Chromatin Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Nucleosome Disassembly Positive Regulation Of Double-strand Break Repair Protein-DNA Complex Disassembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Differentiation Nucleoplasm BBAF Complex Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Positive Regulation Of Cell Differentiation Protein-containing Complex Disassembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Double-strand Break Repair Regulation Of Chromosome Organization Nucleosomal DNA Binding Brahma Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide Positive Regulation Of Lymphocyte Differentiation Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process	Heme O Biosynthetic Process Hemoglobin Metabolic Process Response To Herbicide Response To Cobalt Ion 5-aminolevulinate Synthase Activity Response To Nickel Cation Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Protoporphyrinogen IX Metabolic Process Hemoglobin Biosynthetic Process Heme B Biosynthetic Process T Cell Activation T-helper 1 Type Immune Response NF-kappaB Complex Negative Regulation Of Interferon-beta Production T-helper 1 Cell Differentiation Lymphocyte Activation Cul2-RING Ubiquitin Ligase Complex
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