RDH5 and FDX1

		RDH5	FDX1
Description		retinol dehydrogenase 5	ferredoxin 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body	Mitochondrion Mitochondrial Matrix
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity	Iron Ion Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP P450-containing Electron Transport Chain Cellular Response To Forskolin
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation
Drugs		NADH Vitamin A	Mitotane
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Cognitive function ( 24684796) Coronary artery disease ( 32469254) Serum metabolite levels ( 33031748)
Interacting Genes		5 interacting genes: FDX1 NAB2 ORC4 RGR RLBP1	12 interacting genes: BIRC2 BIRC3 CNTN5 CORO2A CYCS CYP11A1 CYP11B2 FDXR LILRB2 PBRM1 PRKAB2 RDH5
Entrez ID		5959	2230
HPRD ID		03370	00059
Ensembl ID		ENSG00000135437	ENSG00000137714
Uniprot IDs		Q92781	P10109
PDB IDs			3N9Y 3N9Z 3NA0 3NA1 3P1M 7M8I
Enriched GO Terms of Interacting Partners?		P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin	C21-steroid Hormone Biosynthetic Process Steroid Metabolic Process Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Ketone Metabolic Process Alcohol Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Cholesterol Metabolic Process Heme Binding Sterol Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Olefinic Compound Metabolic Process C21-steroid Hormone Metabolic Process Mitochondrial Inner Membrane Steroid Hormone Biosynthetic Process Regulation Of Necroptotic Process Non-canonical NF-kappaB Signal Transduction Ketone Biosynthetic Process Hormone Metabolic Process Regulation Of Programmed Necrotic Cell Death Hormone Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lipid Biosynthetic Process Oxidoreductase Activity Lipid Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Ferredoxin-NADP+ Reductase Activity 11-cis-retinol Dehydrogenase (NAD+) Activity Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Monooxygenase Activity FBXO Family Protein Binding Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Corticosterone 18-monooxygenase Activity Negative Regulation Of Postsynaptic Density Organization MHC Class Ib Protein Complex Binding Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein-containing Complex Binding Small Molecule Metabolic Process Positive Regulation Of Protein K48-linked Ubiquitination
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