FDX1 and CYP11A1

Number of citations of the paper that reports this interaction (PubMedID 1429635)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		FDX1	CYP11A1
Description		ferredoxin 1	cytochrome P450 family 11 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Iron Ion Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP P450-containing Electron Transport Chain Cellular Response To Forskolin	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process C21-steroid Hormone Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid Hormone Biosynthetic Process
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation	Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes AICSR
Drugs		Mitotane	Aminoglutethimide Levoketoconazole
Diseases			Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Cognitive function ( 24684796) Coronary artery disease ( 32469254) Serum metabolite levels ( 33031748)	Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		12 interacting genes: BIRC2 BIRC3 CNTN5 CORO2A CYCS CYP11A1 CYP11B2 FDXR LILRB2 PBRM1 PRKAB2 RDH5	6 interacting genes: CYP11B2 ETFA FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		2230	1583
HPRD ID		00059	00326
Ensembl ID		ENSG00000137714	ENSG00000140459
Uniprot IDs		P10109	A0A0S2Z3R3 P05108
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M 7M8I	3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?		C21-steroid Hormone Biosynthetic Process Steroid Metabolic Process Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Ketone Metabolic Process Alcohol Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Cholesterol Metabolic Process Heme Binding Sterol Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Olefinic Compound Metabolic Process C21-steroid Hormone Metabolic Process Mitochondrial Inner Membrane Steroid Hormone Biosynthetic Process Regulation Of Necroptotic Process Non-canonical NF-kappaB Signal Transduction Ketone Biosynthetic Process Hormone Metabolic Process Regulation Of Programmed Necrotic Cell Death Hormone Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lipid Biosynthetic Process Oxidoreductase Activity Lipid Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Ferredoxin-NADP+ Reductase Activity 11-cis-retinol Dehydrogenase (NAD+) Activity Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Monooxygenase Activity FBXO Family Protein Binding Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Corticosterone 18-monooxygenase Activity Negative Regulation Of Postsynaptic Density Organization MHC Class Ib Protein Complex Binding Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein-containing Complex Binding Small Molecule Metabolic Process Positive Regulation Of Protein K48-linked Ubiquitination	Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Pericardium Development Trophoblast Cell Migration Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Transcription Regulator Complex Endoderm Development MiRNA Processing Hormone Biosynthetic Process Ureteric Bud Development Negative Regulation Of Ossification Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development Mesoderm Formation Response To Growth Factor Phosphatase Binding Electron Transfer Activity Formation Of Primary Germ Layer Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Epithelium Development Response To Transforming Growth Factor Beta Embryonic Skeletal System Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Steroid Biosynthetic Process Cholesterol Metabolic Process Regulation Of Hormone Levels Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Iron Ion Binding Corticosterone 18-monooxygenase Activity Electron Transport Chain Electron Transfer Flavoprotein Complex
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