KLHL12 and CPSF6

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KLHL12	CPSF6
Description		kelch like family member 12	cleavage and polyadenylation specific factor 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane Nuclear Speck Interchromatin Granule Paraspeckles Ribonucleoprotein Complex
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Ribosomal Large Subunit Binding Exon-exon Junction Complex Binding
	Biological Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating	MRNA Processing MRNA 3'-end Processing Positive Regulation Of RNA Export From Nucleus Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways		Degradation of DVL	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
Drugs
Diseases
GWAS			Height ( 18391951) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Pneumoconiosis in silica exposure ( 24986923) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4	50 interacting genes: APBB1 ARMC7 CEBPA CSNK2A1 EWSR1 FOXP1 GIN1 ITCH ITSN2 KLHL12 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR155 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR25 MIR29A MIR34A MIR92A1 MIR93 MIRLET7A1 MIRLET7B MIRLET7C MIRLET7D MIRLET7F2 NCK2 NEDD4 NUDT21 OGT OTUB2 PLSCR1 PPIL1 PRPF40A SRSF7 TOLLIP UBAC1 UBQLN4 USP21 WBP4 WWOX WWP1 WWP2 YES1 ZMYND19
Entrez ID		59349	11052
HPRD ID		13925	05401
Ensembl ID		ENSG00000117153	ENSG00000111605
Uniprot IDs		Q53G59 Q9H7R2	Q16630
PDB IDs		2VPJ 6TTK 6V7O 8OIO 8RBH	3P5T 3P6Y 3Q2S 3Q2T 4B4N 4U0A 4U0B 4WYM 6AY9 6GX9 7SNQ 7ZUD 8CL1 8EJL 8GDV 9CNV
Enriched GO Terms of Interacting Partners?		Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Negative Regulation Of Locomotion MRNA Destabilization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Destabilization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cholesterol Efflux Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Transport Negative Regulation Of Cholesterol Transport Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
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