SENP2 and FUNDC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SENP2	FUNDC1
Description		SUMO specific peptidase 2	FUN14 domain containing 1
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body PML Body Nuclear Membrane	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity	Protein Binding
	Biological Process	Proteolysis Heart Development Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of DNA Endoreduplication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Regulation Of Macromolecule Metabolic Process Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Autophagy Of Mitochondrion Mitophagy Response To Hypoxia Autophagy Mitochondrial Fusion
Pathways		SUMO is proteolytically processed	Receptor Mediated Mitophagy
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28135244) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462 31152163) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 26969751 27841878)	Facial morphology (factor 22) ( 28441456) Personality dimensions ( 18957941)
Interacting Genes		40 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP AR ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63	15 interacting genes: CTBP1 CTBP2 EHHADH GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MARCHF5 MTERF3 SENP2 SH3GLB1 SLC25A46 SNX1 TUFM YES1
Entrez ID		59343	139341
HPRD ID		07002	06658
Ensembl ID		ENSG00000163904	ENSG00000069509
Uniprot IDs		Q9HC62	Q8IVP5
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK	2N9X 5GMV
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Regulation Of Proteolysis Nuclear Membrane Protein Modification By Small Protein Conjugation Protein Localization To Nucleus PML Body Protein Tag Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Import Into Nucleus Nuclear Envelope Import Into Nucleus Very-low-density Lipoprotein Particle Chromatin Organization Post-translational Protein Modification Endoplasmic Reticulum Tubular Network Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Localization Sequence Binding High-density Lipoprotein Particle Regulation Of Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate-density Lipoprotein Particle Nucleus Organization Protein Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process PML Body Organization Chromatin Remodeling Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Regulation Of Protein Localization Molecular Condensate Scaffold Activity Programmed Cell Death Protein Modification Process NLS-dependent Protein Nuclear Import Complex Meiotic Nuclear Membrane Microtubule Tethering Complex	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagy Of Mitochondrion Autophagosome Maturation Autophagy Mitophagy Cellular Response To Starvation Mitochondrial Outer Membrane Autophagosome Response To Starvation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Response To Nutrient Levels White Fat Cell Differentiation GABA Receptor Binding Ubiquitin Protein Ligase Binding Viral Genome Replication Fat Cell Differentiation Mitochondrion Organelle Assembly NAD Binding Cytoplasmic Vesicle Beta-tubulin Binding Transcription Coregulator Binding Catabolic Process Membrane Fission Organelle Membrane Protein-containing Complex Organization Transcription Corepressor Binding Protein Localization To Vacuolar Membrane Microtubule Binding Cellular Response To Amino Acid Starvation Transcription Repressor Complex Response To Amino Acid Starvation Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Mitochondrial Membrane Fission Cellular Component Assembly Positive Regulation Of Membrane Tubulation Microtubule Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Retromer, Tubulation Complex Leptin Receptor Binding
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