KDM5A and VDR

Number of citations of the paper that reports this interaction (PubMedID 11358960)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KDM5A	VDR
Description		lysine demethylase 5A	vitamin D receptor
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Histone Binding Metal Ion Binding Dioxygenase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Zinc Ion Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Circadian Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Facultative Heterochromatin Formation	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Regulation Of DNA-templated Transcription Calcium Ion Transport Intracellular Calcium Ion Homeostasis Lactation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Phosphate Ion Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway MRNA Transcription By RNA Polymerase II Cell-cell Junction Maintenance Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Retinoic Acid Receptor Signaling Pathway Intestinal Absorption Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Negative Regulation Of Phosphate Transmembrane Transport
Pathways		HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)	Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate
Diseases			Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Body mass index ( 26426971) Pulse pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Asthma (adult onset) ( 31036433) Basal cell carcinoma ( 33549134) Eosinophil percentage of white cells ( 32888494) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870) Serum immune biomarker levels ( 32066700)
Interacting Genes		15 interacting genes: CCT6A DSCR9 ESR1 H3-4 H3C1 H3C15 LMO2 NR3C1 PKP2 RARA RB1 RBL1 RNF10 TBP VDR	80 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PRKN PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAG1 STAT1 TAF11 TDG TRIM24 TRIP13 UBR5 ZBTB16
Entrez ID		5927	7421
HPRD ID		08915	03463
Ensembl ID		ENSG00000073614	ENSG00000111424
Uniprot IDs		P29375	A0A5K1VW50 F1D8P8 P11473
PDB IDs		2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF 7KLO 7KLR	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2 7QPP 8IQN 8IQT
Enriched GO Terms of Interacting Partners?		DNA Binding Nuclear Receptor Activity Protein-DNA Complex Assembly Chromatin Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Kinase Activity Nucleoplasm Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Estrogen Response Element Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Structural Constituent Of Chromatin Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Estrogen Stimulus Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Core Promoter Sequence-specific DNA Binding Nucleosome Assembly Branching Involved In Mammary Gland Duct Morphogenesis Nucleosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Hormone-mediated Signaling Pathway Transcription Coactivator Activity Transcription Corepressor Activity Nucleobase-containing Compound Biosynthetic Process DNA-binding Transcription Factor Binding Intracellular Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription
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