RARG and RHPN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RARG	RHPN2
Description		retinoic acid receptor gamma	rhophilin Rho GTPase binding protein 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Membrane RNA Polymerase II Transcription Regulator Complex	Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Chondrocyte Development Glandular Epithelial Cell Development Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Regulation Of DNA-templated Transcription Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Programmed Cell Death Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Reproductive Structure Development Gland Development Canonical Wnt Signaling Pathway Limb Development Face Development Bone Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cartilage Development Harderian Gland Development Cellular Response To Retinoic Acid Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Stem Cell Proliferation	Glomerular Filtration Signal Transduction Negative Regulation Of Stress Fiber Assembly
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 Palovarotene LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
Diseases
GWAS		Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cardiorespiratory fitness (800m run time) ( 32572135) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)	Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 19011631 24737748 24836286 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		35 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NEK9 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRIM1 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576	6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1
Entrez ID		5916	85415
HPRD ID		01573	10192
Ensembl ID		ENSG00000172819	ENSG00000131941
Uniprot IDs		A8K3H3 B7Z4B4 F1D8P1 P13631	Q8IUC4
PDB IDs		1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0	2VSV
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Chromatin Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulator Complex Retinoic Acid-responsive Element Binding Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleosome Disassembly Protein-DNA Complex Disassembly Nuclear Steroid Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding DNA Binding Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Response To Nutrient Levels Regulation Of Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of Bone Mineralization Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Primary Metabolic Process Positive Regulation Of Myoblast Differentiation Somitogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Apoptotic Process Programmed Cell Death Cell Death Tissue Morphogenesis Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure I-SMAD Binding Regulation Of Modification Of Synaptic Structure Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Regulation Of Programmed Cell Death Negative Regulation Of Chondrocyte Differentiation Tissue Development Negative Regulation Of Cartilage Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Anatomical Structure Formation Involved In Morphogenesis Wnt Signaling Pathway Negative Regulation Of Cell Migration Tube Morphogenesis Positive Regulation Of Stress Fiber Assembly Cell Surface Receptor Signaling Pathway Morphogenesis Of An Epithelium Membrane Invagination Non-canonical Wnt Signaling Pathway Regulation Of Chondrocyte Differentiation SMAD Binding Cleavage Furrow Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of Actin Filament Bundle Assembly Rho Protein Signal Transduction Mitotic Cytokinesis Signal Transduction Cell Differentiation Regulation Of Cartilage Development Regulation Of Developmental Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Regulation Of Cell Size Engulfment Of Target By Autophagosome Endothelial Cell Migration Regulation Of Stem Cell Proliferation Cytoskeleton-dependent Cytokinesis Cell Periphery Regulation Of Stress Fiber Assembly Positive Regulation Of Developmental Process Nuclear Receptor-mediated Signaling Pathway Animal Organ Morphogenesis Cellular Developmental Process
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