RALA and RAB8B

Number of citations of the paper that reports this interaction (PubMedID 10889189)
0

Data Source:
HPRD (in vitro, in vivo)

		RALA	RAB8B
Description		RAS like proto-oncogene A	RAB8B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Exosome Flemming Body Synaptic Membrane Schaffer Collateral - CA1 Synapse	Endosome Peroxisomal Membrane Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Cell Tip Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	Nucleotide Binding GTPase Activity Signaling Receptor Binding Protein Binding GTP Binding Hydrolase Activity GDP Binding TPR Domain Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Regulation Of Exocytosis Receptor Internalization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Division Positive Regulation Of Filopodium Assembly Membrane Raft Localization Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Mitochondrial Fission Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Exocytosis Protein Transport Antigen Processing And Presentation Positive Regulation Of Cell Projection Organization Endocytic Recycling Protein Import Into Peroxisome Membrane Positive Regulation Of Corticotropin Secretion Cilium Assembly Cell-substrate Junction Organization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Guanosine-5'-Diphosphate	Phosphoaminophosphonic acid guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS			Refractive error ( 32231278) Serum metabolite levels ( 23093944) Social communication problems ( 24564958)
Interacting Genes		37 interacting genes: ACTB AKAP10 ARF1 C1QC CALM1 CNKSR2 CTCF EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA GCK GLS2 HOXA2 HSPB1 INHBA LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RASSF5 REPS1 RGL2 RGL4 SMAD4 SNCA YBX3	8 interacting genes: APP CDH1 RAB3IP RALA TUBA4A TUBB VIM VPS13C
Entrez ID		5898	51762
HPRD ID		01549	11476
Ensembl ID		ENSG00000006451	ENSG00000166128
Uniprot IDs		P11233	Q92930
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV 6P0I 6P0J 6P0K 6P0L 6P0M 6P0N 6P0O 7NQC 8FJH 8FJI
Enriched GO Terms of Interacting Partners?		Vesicle Tethering Involved In Exocytosis Exocyst Vesicle Tethering Vesicle Docking Involved In Exocytosis Membrane Fission Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Mitotic Cytokinesis Exocytosis Cytoskeleton-dependent Cytokinesis Golgi To Plasma Membrane Transport Vesicle-mediated Transport To The Plasma Membrane Secretion By Cell Organelle Localization Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Small GTPase Binding Secretion Membrane Organization Intracellular Protein Localization Flemming Body Establishment Of Protein Localization Localization Within Membrane Protein Transport Perinuclear Region Of Cytoplasm Golgi Vesicle Transport Regulation Of Norepinephrine Uptake Regulation Of Ral Protein Signal Transduction Transporter Regulator Activity Ras Protein Signal Transduction Cellular Localization Intracellular Signaling Cassette Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cytoplasm Plasma Membrane Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Macrophage Differentiation Growth Cone Membrane Regulation Of Autophagy Platelet Aggregation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Growth Cone Small GTPase-mediated Signal Transduction Positive Regulation Of Hormone Secretion Homotypic Cell-cell Adhesion Cytosol Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Extracellular Exosome Cellular Localization Nuclear Envelope Lumen GTPase Activating Protein Binding Structural Constituent Of Cytoskeleton Negative Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Plasma Membrane Bounded Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cell Development GTP Binding Regulation Of Receptor Internalization Cell Body Acetylcholine Receptor Activator Activity Lipoprotein Particle Cell Projection Organization Positive Regulation Of Protein Import Edg-2 Lysophosphatidic Acid Receptor Binding Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Ciliary Basal Body-plasma Membrane Docking PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Neuron Projection Development Post-Golgi Vesicle-mediated Transport Localization Within Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Response To External Biotic Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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