RAG1 and RAG2

Number of citations of the paper that reports this interaction (PubMedID 12861017)
54

Data Source:
HPRD (in vivo, in vitro)

		RAG1	RAG2
Description		recombination activating 1	recombination activating 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Nucleus Nucleoplasm DNA Recombinase Complex
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endonuclease Activity	DNA Binding Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate Binding Histone H3K4me3 Reader Activity
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Chromatin Organization Immune Response Visual Learning B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Regulation Of Behavioral Fear Response	Mature B Cell Differentiation Involved In Immune Response B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment DNA Recombination Chromatin Organization B Cell Differentiation T Cell Differentiation T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus V(D)J Recombination Organ Growth Defense Response To Bacterium Positive Regulation Of Organ Growth DN2 Thymocyte Differentiation
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)	Rheumatoid arthritis ( 24390342)
Interacting Genes		24 interacting genes: APOF APP CAPRIN1 CDC34 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4C16 HMGB1 HMGB2 KPNA1 KPNA2 PAX6 RAG2 SNX6 TBCA TP53 UBC UBE2C UBE2D1 UBE2D2 UBE2H	7 interacting genes: CAPRIN1 FOXP1 IPO5 LMO2 RAG1 RCN1 SKP2
Entrez ID		5896	5897
HPRD ID		01556	08913
Ensembl ID		ENSG00000166349	ENSG00000175097
Uniprot IDs		P15918	P55895
PDB IDs			8T4R
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Ubiquitin Conjugating Enzyme Activity V(D)J Recombination Structural Constituent Of Chromatin Protein Heterodimerization Activity Protein K48-linked Ubiquitination Somatic Cell DNA Recombination Nucleosome Assembly RAGE Receptor Binding Nucleus Nucleosome Nucleoplasm Nucleosome Organization Molecular Function Activator Activity Protein-DNA Complex Assembly Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Chemoattractant Activity Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex Assembly Proteolysis Involved In Protein Catabolic Process Chromosome Supercoiled DNA Binding B Cell Lineage Commitment Protein Modification By Small Protein Conjugation Positive Chemotaxis Epigenetic Regulation Of Gene Expression Protein Polyubiquitination DNA Binding DNA Metabolic Process DNA Geometric Change Protein-containing Complex Cell Activation Involved In Immune Response Protein-containing Complex Organization DNA Topological Change NLS-dependent Protein Nuclear Import Complex Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Chromosome Organization Post-translational Protein Modification Catabolic Process Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Differentiation Regulation Of MiRNA Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle	Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process Double-stranded DNA Endonuclease Activity Negative Regulation Of Leukocyte Apoptotic Process DNA Recombinase Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-21 Production
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