RAD51D and ZBTB42

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAD51D	ZBTB42
Description		RAD51 paralog D	zinc finger and BTB domain containing 42
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Muscle Organ Development
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS			HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7	50 interacting genes: AIRIM ANKS1A ASB6 ATG9A BLK CABP5 CATSPER1 CCDC102B CDR2L CIDEC CINP CLIC3 CRY2 DYNC1H1 FMR1 GEM GOLGA2 GUCD1 HSD3B7 HSF2BP KANK2 KCTD9 KRT40 MAGOHB MAPK1 MDFI MID2 MKRN3 MYLIP NCK2 NDOR1 NOC4L OAZ3 OSGIN1 OSTF1 OTX1 PIN1 PLA2G6 POLR1C RAD51D SNX18 SPG21 TRAPPC2L TRIM68 TTC23 UBASH3A USHBP1 ZBTB16 ZBTB7B ZNF330
Entrez ID		5892	100128927
HPRD ID		04261	19441
Ensembl ID		ENSG00000185379	ENSG00000179627
Uniprot IDs		O75771	B2RXF5
PDB IDs		2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process	Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?