RAD21 and WAPL

Number of citations of the paper that reports this interaction (PubMedID 17112726)
39

Data Source:
HPRD (in vivo)

		RAD21	WAPL
Description		RAD21 cohesin complex component	WAPL cohesin release factor
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intercellular Bridge Mitotic Spindle
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding	Protein Binding ATP-dependent Protein-DNA Unloader Activity
	Biological Process	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Mitotic Sister Chromatid Segregation Negative Regulation Of DNA Replication Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Parental longevity (father's age at death) ( 31484785)
Interacting Genes		30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	7 interacting genes: ARAP1 BTG3 CDCA5 MTNR1A RAD21 SUMO2 XRN1
Entrez ID		5885	23063
HPRD ID		05924	11072
Ensembl ID		ENSG00000164754	ENSG00000062650
Uniprot IDs		O60216	A8K273 B2RTX8 Q7Z5K2
PDB IDs		4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL	4K6J 5HDT
Enriched GO Terms of Interacting Partners?		Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly	Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cellular Response To Puromycin Cellular Response To Cycloheximide
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