RAD9A and RAD17

Number of citations of the paper that reports this interaction (PubMedID 12578958)
26

Data Source:
HPRD (in vitro, in vivo)

		RAD9A	RAD17
Description		RAD9 checkpoint clamp component A	RAD17 checkpoint clamp loader component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break
	Molecular Function	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN	21 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B F2RL1 HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20
Entrez ID		5883	5884
HPRD ID		04788	09124
Ensembl ID		ENSG00000172613	ENSG00000152942
Uniprot IDs		Q99638	A0A0G2JP78 O75943
PDB IDs		3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8	7Z6H 8GNN
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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