RAB4A and GARIN6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAB4A	GARIN6
Description		RAB4A, member RAS oncogene family	golgi associated RAB2 interactor family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	Protein Binding
	Biological Process	Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Aging ( 22773346) Heel bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)
Interacting Genes		33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GARIN6 GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABGAP1 RABGEF1 RBSN RUFY1 SNCA SOD2 STX4 TP53 VPS52 ZNF830	20 interacting genes: BANP CYSRT1 DNAJB9 FHL3 FHL5 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-8 KRTAP3-2 NBPF19 NOTCH2NLA P4HB PDLIM7 RAB14 RAB2A RAB2B RAB4A RAB4B
Entrez ID		5867	196472
HPRD ID		01541	17539
Ensembl ID		ENSG00000168118	ENSG00000180219
Uniprot IDs		A0A087WYT5 P20338	Q8NEG0
PDB IDs		1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Small GTPase Binding Regulation Of Transport Membrane Organization Small GTPase-mediated Signal Transduction Cellular Localization Regulation Of Vesicle-mediated Transport Regulation Of Protein Localization Glutamatergic Synapse Endosome Cytosol Organelle Organization Intracellular Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Targeting Intracellular Signaling Cassette Regulation Of Cellular Component Organization Regulation Of Norepinephrine Uptake Endosomal Transport Regulation Of Secretion By Cell Cytoplasm Transporter Regulator Activity Membrane Fusion Regulation Of Protein Localization To Cell Periphery Intracellular Signal Transduction Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transport Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Secretion Retrograde Transport, Endosome To Golgi Early Endosome Membrane Exocytosis Secretion Post-Golgi Vesicle-mediated Transport Negative Regulation Of Exocytosis Regulation Of Cellular Localization Nuclear DNA Replication Localization Within Membrane Regulation Of Establishment Of Protein Localization Response To Oxidative Stress Cellular Component Assembly Regulation Of Protein Localization To Plasma Membrane Tau Protein Binding	Keratin Filament Intermediate Filament G Protein Activity Insulin-responsive Compartment GTPase Activity Structural Constituent Of Skin Epidermis Structural Molecule Activity GTP Binding Intermediate Filament Organization GDP Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Rab Protein Signal Transduction Early Endosome To Golgi Transport Endosomal Vesicle Fusion Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion Golgi Vesicle Transport Organelle Fusion Z Disc Recycling Endosome Epidermis Development Membrane Fusion Cytoplasmic Vesicle Membrane Organelle Organization Extracellular Exosome Early Endosome Membrane Autophagosome Membrane Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Procollagen-proline 4-dioxygenase Complex Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
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