RAB3B and SGSM2

Number of citations of the paper that reports this interaction (PubMedID 21808068)
55

Data Source:
BioGRID (two hybrid)

		RAB3B	SGSM2
Description		RAB3B, member RAS oncogene family	small G protein signaling modulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Dopaminergic Synapse	Cytoplasm Cytoplasmic Vesicle Melanosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Myosin V Binding	GTPase Activator Activity Small GTPase Binding
	Biological Process	Exocytosis Protein Transport Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Vesicle Size Regulation Of Synaptic Vesicle Cycle	Late Endosome To Golgi Transport
Pathways		RAB geranylgeranylation
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494)	Aortic root size ( 19584346) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fasting blood proinsulin levels ( 23263489) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Proinsulin levels ( 21873549) Schizophrenia ( 25056061)
Interacting Genes		15 interacting genes: ACVR1 CALM1 CALM2 CALM3 CHM GDI1 PIGR RIMS2 RPH3A RPH3AL SGSM2 SMAD1 SMAD4 TGFBR1 VRTN	21 interacting genes: AFP CA12 CELSR3 CHD3 DSCR9 EGFR FNBP1L GDPD2 ILF2 KHDRBS3 MPP1 MTDH PNO1 PTN RAB2A RAB2B RAB3A RAB3B RAB9B RGMA RPS25
Entrez ID		5865	9905
HPRD ID		01540	15284
Ensembl ID		ENSG00000169213	ENSG00000141258
Uniprot IDs		P20337	B9A6J3 O43147
PDB IDs		3DZ8 8A4B 8A4C
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Adenylate Cyclase Activator Activity Myelin Sheath Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Small GTPase Binding Vesicle-mediated Transport Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling I-SMAD Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Negative Regulation Of Transporter Activity Calcium Channel Complex Transforming Growth Factor Beta Receptor Signaling Pathway Protein-containing Complex Calcineurin-mediated Signaling Activin Receptor Signaling Pathway Detection Of Chemical Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Signaling Cassette Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Synaptic Vesicle Membrane Response To Calcium Ion Transmembrane Transporter Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Spindle Microtubule Transforming Growth Factor Beta Receptor Activity, Type I Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Calcium Channel Regulator Activity SMAD Binding Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Spontaneous Neurotransmitter Secretion	Estrous Cycle GTPase Activity GTP Binding GDP Binding Myosin V Binding Ovulation Cycle Acrosomal Vesicle GTP-dependent Protein Binding Regulation Of Axon Regeneration
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