RAB1A and MICAL1

Number of citations of the paper that reports this interaction (PubMedID 12788069)
0

Data Source:
BioGRID (pull down)

		RAB1A	MICAL1
Description		RAB1A, member RAS oncogene family	microtubule associated monooxygenase, calponin and LIM domain containing 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Melanosome Extracellular Exosome	Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Intermediate Filament Actin Filament Plasma Membrane Cilium Endosome Membrane Actin Cytoskeleton Membrane Midbody Ciliary Basal Body Intercellular Bridge Plasma Membrane Bounded Cell Projection Hippocampal Mossy Fiber Expansion
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Cadherin Binding Metal Ion Binding	Actin Binding Monooxygenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding F-actin Monooxygenase Activity
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Autophagy Golgi Organization Protein Transport Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Positive Regulation Of Interleukin-8 Production Substrate Adhesion-dependent Cell Spreading Defense Response To Bacterium Vesicle Transport Along Microtubule Cilium Assembly COPII-coated Vesicle Cargo Loading Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process	Cytoskeleton Organization Signal Transduction Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Triglyceride levels ( 32154731)	Depression in smokers ( 30219690) Height ( 28552196)
Interacting Genes		35 interacting genes: ADCK1 CAPNS1 CDKN1A CHML CREB1 CSNK1D EBP FNDC3B FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 MTOR OCRL PLK1 PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RFK RUSC2 SLC16A8 SNCA SNRNP27 SNRPG SSX2IP SYT5 TBC1D17 USO1 ZNF593	17 interacting genes: ABL1 CRK DNAH5 EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM
Entrez ID		5861	64780
HPRD ID		01538	06183
Ensembl ID		ENSG00000138069	ENSG00000135596
Uniprot IDs		B7Z8M7 P62820 Q5U0I6	Q8TDZ2
PDB IDs		2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS 7EQ2 9MHF 9MHG 9MHH	1WYL 2CO8 2DK9 5LE0 5LPN 6KU0 8HLO 8Y6K 9EWY
Enriched GO Terms of Interacting Partners?		Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Small GTPase Binding Golgi Organization Protein Prenylation Vesicle-mediated Transport Organelle Organization Golgi Vesicle Transport Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Prenyltransferase Activity Cytoplasm Organelle Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Protein Localization To Cytoskeleton Centrosome Cycle Cis-Golgi Network Establishment Of Localization In Cell Prenyltransferase Activity Protein Destabilization Cytoplasmic Vesicle Protein Localization To Cilium Spindle Organization Cytosol Ciliary Basal Body Cadherin Binding Intracellular Transport Behavioral Response To Cocaine Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization Cell Projection Assembly Spindle Assembly Protein Serine/threonine Kinase Binding Protein Localization To Organelle GTPase Activator Activity Chemotaxis To Arachidonate Regulation Of Protein-containing Complex Assembly Microtubule Nucleation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cilium Assembly Cellular Component Assembly Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Organelle Assembly	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion SH2 Domain Binding Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Organelle Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Cell Migration Scaffold Protein Binding Positive Regulation Of Cell Motility Negative Regulation Of Anoikis ERBB Signaling Pathway Positive Regulation Of Locomotion Nucleotide Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Establishment Of Cell Polarity Regulation Of Cell Projection Organization Protein Domain Specific Binding Regulation Of Anoikis Integrin-mediated Signaling Pathway Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cellular Response To Fluid Shear Stress Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Epithelial Cell Development Regulation Of Cytoskeleton Organization Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Metabolic Process Developmental Process Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Mononuclear Cell Migration
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