BCAT1 and SOX5

		BCAT1	SOX5
Description		branched chain amino acid transaminase 1	SRY-box transcription factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus
	Molecular Function	Catalytic Activity Branched-chain-amino-acid Transaminase Activity Protein Binding Transaminase Activity Transferase Activity L-leucine-2-oxoglutarate Transaminase Activity L-valine-2-oxoglutarate Transaminase Activity L-isoleucine-2-oxoglutarate Transaminase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Lipid Metabolic Process Amino Acid Biosynthetic Process Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Cartilage Development Asymmetric Neuroblast Division Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Branched-chain amino acid catabolism
Drugs		Pyridoxal phosphate Glutamic acid Leucine Valine Isoleucine N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
Diseases
GWAS		Adventurousness ( 30643258) Atrial fibrillation ( 29892015) Body size at age 10 ( 32376654) Breast cancer ( 31757997) Calcium levels ( 25972035) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Major depressive disorder x sex interaction ( 34099189) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) PR interval ( 30679814 32439900) Pulse pressure ( 30224653) Response to statin therapy ( 20339536) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Uterine fibroid size (maximum volume) ( 30196971)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) AIDS ( 19754311) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 29325848) Body mass index ( 25673413) Chronic back pain ( 30261039) Chronotype ( 30696823) Creatinine levels ( 29403010) Depression ( 29700475) Glomerular filtration rate ( 29403010) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Juvenile osteochondritis dissecans ( 26422391) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mortality in sepsis ( 27639821) Multisite chronic pain ( 33830993) Non-obstructive azoospermia ( 22197933) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Pelvic organ prolapse (moderate/severe) ( 26545240) PR interval ( 30046033 20062060 29127183 32439900) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656) Systemic sclerosis ( 21779181) Systolic blood pressure ( 30224653) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: C17orf75 CEBPA ENKD1 KDM1A PRMT6 SMAD5 SOX5 TRIM55 TRIM63	46 interacting genes: ABCC9 APP ARID5A BCAT1 BIRC7 C2CD5 CAMK2A CBX8 CDC23 CDC25A CDK6 CRX FOXP1 FOXP2 FOXP4 FTH1 FXR1 HNF1B IRAG2 KAT5 KIFC3 LMO1 LMO2 MAGED1 MED27 MORN3 MSX2 NFIC NFIX PIAS2 PRR20A RNF4 RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TENT5B TEX11 TRAF2 TTC1 UBE2I UQCRFS1 ZBTB26 ZNF581
Entrez ID		586	6660
HPRD ID		00216	18086
Ensembl ID		ENSG00000060982	ENSG00000134532
Uniprot IDs		P54687	F5H0I3 P35711 T2CYZ2
PDB IDs		2ABJ 2COG 2COI 2COJ 7NTR 7NWA 7NWB 7NWC 7NWE 7NWM 7NXN 7NXO 7NY2 7NY9 7NYA
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Stem Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Differentiation Response To Vitamin B2 C/EBP Complex Regulation Of Cell Differentiation Negative Regulation Of Fas Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Microtubule Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of DNA-templated Transcription Regulation Of Osteoblast Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process DNA-binding Transcription Factor Binding Chromatin DNA-binding Transcription Factor Activity White Fat Cell Proliferation Response To Glucocorticoid Response To Corticosteroid Negative Regulation Of RNA Biosynthetic Process Cell Maturation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Developmental Process Fat Cell Proliferation Cartilage Development Regulation Of Fas Signaling Pathway Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Mullerian Duct Regression Osteoblast Fate Commitment Cell Fate Commitment SMAD Protein Complex DEAD/H-box RNA Helicase Binding Asymmetric Neuroblast Division Positive Regulation Of Mesenchymal Stem Cell Differentiation	Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Chromatin Nucleus Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Heteromeric SMAD Protein Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Nucleoplasm Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Mesonephric Tubule Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mesonephric Epithelium Development I-SMAD Binding Cardiac Conduction System Development Stem Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Transcription Factor Binding Osteoblast Fate Commitment Striated Muscle Tissue Development Identical Protein Binding Epithelium Development Kidney Epithelium Development Positive Regulation Of RNA Metabolic Process Mitotic Cell Cycle Phase Transition Muscle Tissue Development
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