MID1IP1 and TSHR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MID1IP1	TSHR
Description		MID1 interacting protein 1	thyroid stimulating hormone receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Identical Protein Binding Ligase Regulator Activity	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	Lipid Metabolic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Protein Polymerization Positive Regulation Of Ligase Activity	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Carnitine shuttle	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Thyrotropin alfa
Diseases			Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Response to metformin (IC50) ( 28173075)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		7 interacting genes: AK8 APOE GSK3B MID1 MID2 SUFU TSHR	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB
Entrez ID		58526	7253
HPRD ID		06732	04537
Ensembl ID		ENSG00000165175	ENSG00000165409
Uniprot IDs		Q9NPA3	P16473
PDB IDs			2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Tau Protein Binding Enzyme Binding Artery Development Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Regulation Of Proteolysis Negative Regulation Of Protein Localization Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Protein Localization To Nucleus Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Microtubule Protein Localization To Cytoskeleton Phosphoprotein Binding Cellular Response To Thyrotropin-releasing Hormone Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Regulation Of Axon Extension Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Intracellular Signal Transduction Lipid Transport Involved In Lipid Storage Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Beta-catenin Binding Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Response To Drug Regulation Of Establishment Of Protein Localization Modulation Of Process Of Another Organism Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Transport	G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure
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