SELENOK and GPR35

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SELENOK	GPR35
Description		selenoprotein K	G protein-coupled receptor 35
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Monoatomic Ion Transport Calcium Ion Transport Response To Oxidative Stress Macrophage Derived Foam Cell Differentiation Protein Palmitoylation Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Respiratory Burst After Phagocytosis Regulation Of Calcium-mediated Signaling Regulation Of Protein Transport Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Monocyte Chemotactic Protein-1 Production T Cell Migration Positive Regulation Of Neutrophil Migration Neutrophil Migration Positive Regulation Of T Cell Migration	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Class A/1 (Rhodopsin-like receptors)
Drugs			Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS			Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		42 interacting genes: AMIGO1 AQP6 BIK C6orf47 CLN8 CNR2 COMT CPLX4 CREB3 ERBB2 ERBB3 ERBB4 ERGIC3 FAM209A FFAR2 FKBP7 GLP1R GORAB GPR35 GPX8 IL10RA KLHDC2 LMNA MFSD6 MMD MRM1 MTIF3 MUC1 REEP4 RNF19B SAR1A SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35E3 SLC35H1 STMN4 STOM TMEM31 TMPRSS2 TMX2	58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		58515	2859
HPRD ID		07448	16003
Ensembl ID		ENSG00000113811	ENSG00000178623
Uniprot IDs		Q9Y6D0	A8K2J1 B2RA17 Q9HC97
PDB IDs		6DO3	8H8J
Enriched GO Terms of Interacting Partners?		Membrane ERBB3:ERBB2 Complex Neuregulin Receptor Activity ERBB2 Signaling Pathway ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Bile Acid:sodium Symporter Activity Norepinephrine Transport ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
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