BBS4 and CALCA

Number of citations of the paper that reports this interaction (PubMedID 18000879)
0

Data Source:
BioGRID (two hybrid)

		BBS4	CALCA
Description		Bardet-Biedl syndrome 4	calcitonin related polypeptide alpha
Image
GO Annotations	Cellular Component	Pericentriolar Material Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Signaling Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding Protein-containing Complex Binding Receptor Ligand Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neuron Migration Leukocyte Homeostasis B Cell Homeostasis Neural Tube Closure Retina Homeostasis Heart Looping Lymphocyte Homeostasis Myeloid Cell Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Centrosome Cycle Spermatid Development Sensory Perception Visual Perception Sensory Perception Of Smell Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Protein Transport Wnt Signaling Pathway Dendrite Development Regulation Of Lipid Metabolic Process Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Negative Regulation Of Actin Filament Polymerization Melanosome Transport Regulation Of Cytokinesis Leptin-mediated Signaling Pathway Protein Localization To Organelle Erythrocyte Homeostasis Microtubule Anchoring At Centrosome Social Behavior Photoreceptor Cell Outer Segment Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Brain Morphogenesis Homeostasis Of Number Of Cells Sensory Processing Maintenance Of Protein Location In Nucleus Regulation Of Stress Fiber Assembly Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Adipose Tissue Development Fat Pad Development Protein Localization To Cilium Protein Localization To Centrosome Sperm Flagellum Assembly Regulation Of Non-motile Cilium Assembly Protein Localization To Photoreceptor Outer Segment Non-motile Cilium Assembly	Response To Yeast Endothelial Cell Proliferation Vasculature Development Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Embryo Implantation Regulation Of Blood Pressure Negative Regulation Of Calcium Ion Transport Into Cytosol Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Vasodilation Endothelial Cell Migration Innate Immune Response Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Contraction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Tumor Necrosis Factor Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		BBSome-mediated cargo-targeting to cilium	G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs			Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Mild obesity-related type 2 diabetes ( 34737425) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)
Interacting Genes		28 interacting genes: AAGAB ACTB ANP32A BHMT CALCA CATSPERT DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB IGDCC3 KRT18 MRPL28 MYOG OAS1 PAX2 PCM1 RARA RARG REL SEMA7A SPIRE1 TOM1 TOM1L2 ZIC1	8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2
Entrez ID		585	796
HPRD ID		08982	00238
Ensembl ID		ENSG00000140463	ENSG00000110680
Uniprot IDs		A0A0S2Z3A9 B4DQR5 Q96RK4	P01258 P06881
PDB IDs		6XT9	2JXZ 6E3Y 7KNU 7TYH 7TYO 9AUC
Enriched GO Terms of Interacting Partners?		Nucleus Localization Nuclear Migration Trachea Cartilage Development Glandular Epithelial Cell Development Centriolar Satellite DNA-binding Transcription Factor Activity Microtubule Anchoring At Centrosome Embryonic Organ Development Growth Plate Cartilage Development Positive Regulation Of Metabolic Process Cytoplasm Regulation Of Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Cytosol Response To Peptide Vesicle-mediated Transport Response To Cytokine Microtubule Anchoring At Microtubule Organizing Center Surfactant Homeostasis Cis-regulatory Region Sequence-specific DNA Binding Tube Closure Camera-type Eye Development Cellular Response To Retinoic Acid Neural Tube Closure Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Development Nucleoplasm Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Biosynthetic Process Microtubule Organizing Center Positive Regulation Of Cell Development Positive Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Response To Retinoic Acid Retinoic Acid Receptor Signaling Pathway Face Development Microtubule Anchoring Positive Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Localization Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Organelle Localization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Eye Development Protein-containing Complex Tube Formation Negative Regulation Of Cartilage Development Chromatin	Calcitonin Family Receptor Signaling Pathway Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Amylin Receptor Signaling Pathway BBSome Receptor Internalization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Striatum Development Regulation Of Cilium Beat Frequency Retina Homeostasis Brain Morphogenesis Ventricular System Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Face Development Regulation Of Blood Pressure Receptor-mediated Endocytosis Protein Localization To Plasma Membrane Establishment Of Protein Localization Regulation Of Cilium Movement Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Photoreceptor Cell Maintenance Calcium Ion Transport Dendrite Development Heart Development Non-motile Cilium Assembly Regulation Of Microtubule-based Movement G Protein-coupled Receptor Signaling Pathway Ciliary Membrane Protein Localization To Membrane Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Coreceptor Activity Protein Localization To Cilium Endothelin Maturation Calcitonin Catabolic Process Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Binding Hippocampus Development Intracellular Protein Localization Sensory Perception Of Smell Cerebral Cortex Development Metalloendopeptidase Activity Endocytosis
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