MS4A7 and HMGCL

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MS4A7	HMGCL
Description		membrane spanning 4-domains A7	3-hydroxy-3-methylglutaryl-CoA lyase
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Plasma Membrane Membrane	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	Protein Binding	Magnesium Ion Binding Catalytic Activity Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Lyase Activity Oxo-acid-lyase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Signaling Pathway	L-leucine Catabolic Process Lipid Metabolic Process Mitochondrion Organization Ketone Body Biosynthetic Process
Pathways			Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs			3-hydroxyglutaric acid
Diseases			3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		Iron status biomarkers (ferritin levels) ( 33536631) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		10 interacting genes: CD72 DRAM1 EMP1 HMGCL IGFBP5 ITGB2 LAT PLN PMP22 SLC35F6	13 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 IKBKB MS4A7 NEDD4 PEX5 RNF126 SMARCA4 UBC
Entrez ID		58475	3155
HPRD ID		07579	02003
Ensembl ID		ENSG00000166927	ENSG00000117305
Uniprot IDs		Q9GZW8	P35914
PDB IDs			2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?		Bleb Assembly Apoptotic Process Hydroxymethylglutaryl-CoA Lyase Activity Oxo-acid-lyase Activity Negative Regulation Of Skeletal Muscle Hypertrophy Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process TCR Signalosome Cell Death Programmed Cell Death Insulin-like Growth Factor Binding Protein Complex ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin-mediated Signaling Pathway Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Protein Monoubiquitination Tat Protein Binding Positive Regulation Of DNA Binding Cerebral Cortex Neuron Differentiation Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Modification Process Transcriptional Start Site Selection At RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Forebrain Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Post-translational Protein Modification Protein Targeting Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Fatty Acid Beta-oxidation Transcription Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding Germinal Vesicle Protein-containing Complex Organization Protein-containing Complex Assembly RNA Polymerase II Core Complex Assembly Protein Metabolic Process Lipid Oxidation 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Fatty Acid Catabolic Process Mitochondrial Ribonuclease P Complex Fatty Acid Oxidation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing Protein Tetramerization Protein-folding Chaperone Binding Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Blood Vessel Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
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