PLEKHB1 and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PLEKHB1	RAP1GDS1
Description		pleckstrin homology domain containing B1	Rap1 GTPase-GDP dissociation stimulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Phototransduction Regulation Of Cell Differentiation	Cardiac Muscle Hypertrophy Regulation Of Mitochondrion Organization Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Localization To Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of ERK5 Cascade CAAX-box Protein Maturation Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Matrix Metallopeptidase Secretion
Pathways			RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Dimensional psychopathology (Cognitive) ( 29496196) Glucose homeostasis traits ( 25524916) Hand grip strength ( 27325353) Smoking status (ever vs never smokers) ( 30643258)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		18 interacting genes: ACVR1 ATXN1 BAG3 BMPR1B BTG3 C10orf55 CCR8 DSCR9 GLIS2 GNGT1 LCOR RAP1GDS1 RBM11 RUNX1 SMAD1 TGFBR1 VENTX ZDHHC17	27 interacting genes: ABCB7 AKT1 ANTXR2 CDC42 DIRAS1 DOC2A EGFR HRAS KIFAP3 KRAS LCOR LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAC1 RAP1A RAP2B RHOA RNF19B RRAS2 UBC ZNF451
Entrez ID		58473	5910
HPRD ID		09630	11763
Ensembl ID		ENSG00000021300	ENSG00000138698
Uniprot IDs		Q9UF11	B3KNU0 P52306 Q6U7G8
PDB IDs			5XGC 5ZHX
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Complex Activin Receptor Activity, Type I SMAD Binding Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Activin Binding Regulation Of Cartilage Development BMP Signaling Pathway Striated Muscle Cell Apoptotic Process Cellular Response To Growth Factor Stimulus Pharyngeal System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Apoptotic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Poly(U) RNA Binding Positive Regulation Of RNA Metabolic Process Response To Growth Factor Osteoblast Differentiation Positive Regulation Of Extracellular Matrix Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Extrinsic Apoptotic Signaling Pathway Pattern Specification Process Ventricular Septum Morphogenesis Regulation Of RNA Metabolic Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Cell Fate Commitment Positive Regulation Of Vasculature Development Regulation Of Cardiac Muscle Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Growth Factor Binding Endocardial Cushion Cell Fate Commitment CAAX-box Protein Maturation Perforant Pathway To Dendrate Granule Cell Synapse Cellular Developmental Process	G Protein Activity GTPase Activity GDP Binding GTP Binding Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Glutamatergic Synapse Regulation Of Protein Localization To Membrane Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Locomotion Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorylation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ras Protein Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Positive Regulation Of Epithelial Cell Proliferation Cerebral Cortex Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Process Postsynapse Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Forebrain Radial Glial Cell Differentiation Cell Development Telencephalon Cell Migration Focal Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Positive Regulation Of Cell Cycle Process Cell Migration Forebrain Cell Migration
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