PEX5 and S100A6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PEX5	S100A6
Description		peroxisomal biogenesis factor 5	S100 calcium binding protein A6
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein-containing Complex	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein Carrier Chaperone	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Pexophagy Neuron Migration Protein Monoubiquitination Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Beta-oxidation Mitochondrion Organization Mitochondrial Membrane Organization Endoplasmic Reticulum Organization Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Cerebral Cortex Cell Migration Cerebral Cortex Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Positive Regulation Of Multicellular Organism Growth Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Cell Development Neuromuscular Process Protein Tetramerization	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation
Pathways		Pexophagy
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		77 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 NUFIP2 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53
Entrez ID		5830	6277
HPRD ID		02684	00237
Ensembl ID		ENSG00000139197	ENSG00000197956
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	P06703
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO 7Z0K 9GAG	1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Peroxisome Peroxisomal Matrix Carboxylic Acid Catabolic Process Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Carboxylic Acid Metabolic Process Fatty Acid Catabolic Process Organic Acid Metabolic Process Lipid Oxidation Peroxisome Organization Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Peroxisomal Membrane Transport Peroxisomal Membrane Lipid Modification Protein Import Into Peroxisome Matrix, Receptor Recycling Intracellular Protein Transmembrane Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Small Molecule Metabolic Process Lipid Metabolic Process Protein Unfolding Lipid Catabolic Process Protein Transmembrane Transport Catabolic Process Fatty Acid Beta-oxidation Receptor Recycling Protein Targeting To Peroxisome Cytosol Establishment Of Protein Localization To Organelle Receptor Metabolic Process Sulfur Compound Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Import Into Peroxisome Matrix, Substrate Release Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Oxidoreductase Activity Protein Localization To Organelle Purine-containing Compound Metabolic Process Small Molecule Biosynthetic Process Peroxisomal Importomer Complex Malonyl-CoA Catabolic Process Protein Transmembrane Transporter Activity Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Telomere Assembly Organophosphate Metabolic Process	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation
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