PXN and GART

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PXN	GART
Description		paxillin	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction	Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity ATP Binding Transferase Activity Ligase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Metal Ion Binding
	Biological Process	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway	Brainstem Development Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cerebellum Development Cerebral Cortex Development 'de Novo' AMP Biosynthetic Process Adenine Biosynthetic Process 'de Novo' XMP Biosynthetic Process
Pathways		GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Purine ribonucleoside monophosphate biosynthesis
Drugs			Pemetrexed Glycinamide Ribonucleotide N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acid
Diseases
GWAS		Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)	Crohn's disease ( 23128233) Educational attainment ( 25201988) Psoriasis ( 25854761)
Interacting Genes		89 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK IMPDH2 ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PCM1 PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SCARB1 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN	10 interacting genes: CDC42 IFNAR1 JUN KPNA2 NMI OGT PXN TIAM1 TMPRSS15 TRAF6
Entrez ID		5829	2618
HPRD ID		03937	00716
Ensembl ID		ENSG00000089159	ENSG00000159131
Uniprot IDs		A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023	P22102 Q59HH3
PDB IDs		1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0	1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3 5J9F 7JG0 7JG3 7JG4 8FDX 8FDY 8FE0 8FJV 8FJW 8FJX 8FJY 9NX6
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway	Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Communication Intracellular Signaling Cassette Regulation Of Signaling Myeloid Leukocyte Differentiation Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Cell-cell Junction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Myeloid Cell Differentiation Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Macrophage Activation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cell Surface Receptor Signaling Pathway Via JAK-STAT Mononuclear Cell Differentiation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Host-mediated Perturbation Of Viral Process Cell Surface Receptor Signaling Pathway Via STAT Leukocyte Differentiation GBD Domain Binding Storage Vacuole Type I Interferon Receptor Activity Type I Interferon Binding Interferon Receptor Activity Leading Edge Cell Differentiation Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Response To Virus Positive Regulation Of Cell Population Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Population Proliferation Regulation Of Cell Migration
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