NECTIN2 and NECTIN4

Number of citations of the paper that reports this interaction (PubMedID 21982860)
0

Data Source:
BioGRID (pull down)

		NECTIN2	NECTIN4
Description		nectin cell adhesion molecule 2	nectin cell adhesion molecule 4
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome	Extracellular Region Plasma Membrane Adherens Junction Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Receptor Ligand Activity Cell Adhesion Molecule Binding	Virus Receptor Activity Protein Binding Identical Protein Binding Receptor Ligand Activity Cell Adhesion Mediator Activity
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cellular Anatomical Entity Morphogenesis Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs			Enfortumab vedotin
Diseases			Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		38 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE1E LCE1F LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 RGS20 SIAH1 TCF4 TGM1 TIGIT USP53	6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		5819	81607
HPRD ID		02879	17934
Ensembl ID		ENSG00000130202	ENSG00000143217
Uniprot IDs		Q92692	K4PZ75 Q96NY8
PDB IDs		3R0N 4DFH 4DFI 4HZA 5V52 8X6B	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Intermediate Filament Keratinization Epidermis Development Keratin Filament Cell Adhesion Mediator Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Molecule Binding Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Leukocyte Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mast Cell Activation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Adherens Junction Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Innate Immune Response Cell-cell Contact Zone Cochlea Morphogenesis Semicircular Canal Formation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Neuron Apoptotic Process Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway TRNA-dihydrouridine20 Synthase Activity L-cysteine Desulfurase Complex Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Cell-cell Contact Zone Cell Adhesion Molecule Binding Apical Junction Complex Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor Activity Regulation Of Natural Killer Cell Mediated Immunity Immune Response Virus Receptor Activity Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Leukocyte Mediated Cytotoxicity Cell-cell Adhesion Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Sperm Mitochondrion Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Presynaptic Membrane Innate Immune Response Leukocyte Mediated Immunity Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Identical Protein Binding Membrane Curvature Sensor Activity Defense Response To Symbiont Cell-cell Junction Organization Defense Response To Other Organism Adherens Junction Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Killing Regulation Of Lymphocyte Mediated Immunity Actin Filament Binding Cell-cell Junction Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Adhesion Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Immune Response Positive Regulation Of Mast Cell Activation Growth Cone Membrane Zonula Adherens
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