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NECTIN2 and NECTIN4
Number of citations of the paper that reports this interaction (PubMedID
21982860
)
0
Data Source:
BioGRID
(pull down)
NECTIN2
NECTIN4
Description
nectin cell adhesion molecule 2
nectin cell adhesion molecule 4
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Zonula Adherens
Focal Adhesion
Cell Surface
Membrane
Apical Junction Complex
Cell-cell Contact Zone
Extracellular Exosome
Extracellular Region
Plasma Membrane
Adherens Junction
Membrane
Extracellular Exosome
Anchoring Junction
Molecular Function
Virus Receptor Activity
Protein Binding
Coreceptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Receptor Ligand Activity
Cell Adhesion Molecule Binding
Virus Receptor Activity
Protein Binding
Identical Protein Binding
Receptor Ligand Activity
Cell Adhesion Mediator Activity
Biological Process
Acrosome Assembly
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Positive Regulation Of Immunoglobulin Mediated Immune Response
Cytoskeleton Organization
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Signal Transduction
Spermatid Development
Spermatid Nucleus Differentiation
Fertilization
Fusion Of Virus Membrane With Host Plasma Membrane
Sperm Mitochondrion Organization
Cellular Anatomical Entity Morphogenesis
Positive Regulation Of Mast Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Susceptibility To Natural Killer Cell Mediated Cytotoxicity
Adhesion Of Symbiont To Host
Cilium Organization
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Viral Entry Into Host Cell
Symbiont Entry Into Host Cell
Coreceptor-mediated Virion Attachment To Host Cell
Positive Regulation Of T Cell Receptor Signaling Pathway
Establishment Of Localization In Cell
Establishment Of Mitochondrion Localization
Susceptibility To T Cell Mediated Cytotoxicity
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Signal Transduction
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Symbiont Entry Into Host Cell
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adherens junctions interactions
Nectin/Necl trans heterodimerization
Adherens junctions interactions
Nectin/Necl trans heterodimerization
Drugs
Enfortumab vedotin
Diseases
Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Low density lipoprotein cholesterol levels (
30498476
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Triglyceride levels x long total sleep time interaction (2df test) (
31719535
)
Triglyceride levels x short total sleep time interaction (2df test) (
31719535
)
Urate levels (
31578528
)
Interacting Genes
39 interacting genes:
AFDN
ATP5MF
CD226
CYSRT1
DUS2
HOXA1
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP12-2
KRTAP5-9
LCE1C
LCE1E
LCE1F
LCE2B
LCE2C
LCE5A
LYRM4
MAPK6
MDFI
MEOX2
NBPF19
NECTIN3
NECTIN4
NOTCH2NLA
NR4A3
P4HB
PICK1
PVR
RGS20
SIAH1
TCF4
TGM1
TIGIT
USP53
6 interacting genes:
AFDN
DEFB121
NECTIN1
NECTIN2
PICK1
TIGIT
Entrez ID
5819
81607
HPRD ID
02879
17934
Ensembl ID
ENSG00000130202
ENSG00000143217
Uniprot IDs
Q92692
K4PZ75
Q96NY8
PDB IDs
3R0N
4DFH
4DFI
4HZA
5V52
8X6B
4FRW
4GJT
4JJH
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Intermediate Filament
Keratinization
Epidermis Development
Keratin Filament
Cell Adhesion Mediator Activity
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Natural Killer Cell Mediated Immunity
Tissue Development
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Cell Adhesion Molecule Binding
Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell
Regulation Of Leukocyte Mediated Cytotoxicity
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Mast Cell Activation
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Natural Killer Cell Mediated Immunity
Leukocyte Mediated Cytotoxicity
Positive Regulation Of Immune Response To Tumor Cell
Regulation Of Mast Cell Activation
Adherens Junction
Regulation Of Lymphocyte Mediated Immunity
Negative Regulation Of Innate Immune Response
Cell-cell Contact Zone
Cochlea Morphogenesis
Semicircular Canal Formation
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Response To Tumor Cell
Neuron Apoptotic Process
Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway
TRNA-dihydrouridine20 Synthase Activity
L-cysteine Desulfurase Complex
Symbiont Entry Into Host Cell
Lymphocyte Mediated Immunity
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-cell Contact Zone
Cell Adhesion Molecule Binding
Apical Junction Complex
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Natural Killer Cell Mediated Cytotoxicity
Natural Killer Cell Mediated Immunity
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Coreceptor Activity
Regulation Of Natural Killer Cell Mediated Immunity
Immune Response
Virus Receptor Activity
Coreceptor-mediated Virion Attachment To Host Cell
Cellular Anatomical Entity Morphogenesis
Leukocyte Mediated Cytotoxicity
Cell-cell Adhesion
Negative Regulation Of Innate Immune Response
Regulation Of Leukocyte Mediated Cytotoxicity
Symbiont Entry Into Host Cell
Susceptibility To T Cell Mediated Cytotoxicity
Lymphocyte Mediated Immunity
Sperm Mitochondrion Organization
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Presynaptic Membrane
Innate Immune Response
Leukocyte Mediated Immunity
Fusion Of Virus Membrane With Host Plasma Membrane
Susceptibility To Natural Killer Cell Mediated Cytotoxicity
Biological Process Involved In Interaction With Host
Identical Protein Binding
Membrane Curvature Sensor Activity
Defense Response To Symbiont
Cell-cell Junction Organization
Defense Response To Other Organism
Adherens Junction
Immune System Process
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Cell Killing
Regulation Of Lymphocyte Mediated Immunity
Actin Filament Binding
Cell-cell Junction
Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell
Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cell Adhesion
Cell Development
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Plasma Membrane Bounded Cell Projection Organization
Negative Regulation Of Immune Response
Positive Regulation Of Mast Cell Activation
Growth Cone Membrane
Zonula Adherens
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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