PTX3 and FGF20

Number of citations of the paper that reports this interaction (PubMedID 25912421)
45

Data Source:
BioGRID (pull down)

		PTX3	FGF20
Description		pentraxin 3	fibroblast growth factor 20
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding	Signaling Receptor Binding Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparan Sulfate Proteoglycan Binding Receptor-receptor Interaction
	Biological Process	Ovarian Cumulus Expansion Response To Yeast Immune System Process Inflammatory Response Immune Response Opsonization Extracellular Matrix Organization Host-mediated Suppression Of Viral Proces Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Phagocytosis Response To Other Organism Negative Regulation Of Glycoprotein Metabolic Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Neurogenesis Cell Differentiation Regulation Of Cell Migration Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Dopaminergic Neuron Differentiation
Pathways		Neutrophil degranulation	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Allergic rhinitis in asthma ( 25085501) Attention function in attention deficit hyperactive disorder ( 26174813) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) Parkinson's disease ( 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		16 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A SNCA	2 interacting genes: PCM1 PTX3
Entrez ID		5806	26281
HPRD ID		03928	05709
Ensembl ID		ENSG00000163661	ENSG00000078579
Uniprot IDs		P26022	Q9NP95
PDB IDs		7ZL1 8PVQ 8S50	3F1R
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Growth Factor Activity Fibroblast Growth Factor Receptor Binding Extracellular Region Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Type 2 Fibroblast Growth Factor Receptor Binding Extracellular Space Cell-cell Signaling Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Signaling Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of MAPK Cascade Regulation Of Locomotion Complement Component C1q Complex Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Population Proliferation Symbiont Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility IgM Binding Complement Component C1 Complex Positive Regulation Of Intracellular Signal Transduction Type 1 Fibroblast Growth Factor Receptor Binding Positive Regulation Of Cell Division Lung Development Postsynapse Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synapse Pruning Complement Activation Regulation Of Sprouting Angiogenesis IgG Binding Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Animal Organ Morphogenesis Organ Induction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Animal Organ Formation Corticotropin Hormone Secreting Cell Differentiation Developmental Induction Chemoattractant Activity Positive Regulation Of Endothelial Cell Migration	Protein-containing Complex Localization To Centriolar Satellite Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Interkinetic Nuclear Migration Ovarian Cumulus Expansion Intraciliary Transport Involved In Cilium Assembly Complement Component C1q Complex Binding Regulation Of Protein Complex Stability Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Virion Binding Negative Regulation Of Glycoprotein Metabolic Process Opsonization Host-mediated Suppression Of Viral Proces Response To Yeast Pericentriolar Material Positive Regulation Of Transport Microtubule Anchoring Neuronal Stem Cell Population Maintenance Protein Localization To Centrosome Nuclear Migration Host-mediated Suppression Of Symbiont Invasion Nucleus Localization Non-motile Cilium Ciliary Transition Zone Ovulation Cycle Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Cytoskeleton Centrosome Cycle Intraciliary Transport Non-motile Cilium Assembly Social Behavior Tertiary Granule Lumen Specific Granule Lumen Response To Fungus Regulation Of Nitric Oxide Biosynthetic Process Cytoplasmic Microtubule Organization Regulation Of Nitric Oxide Metabolic Process Protein-containing Complex Localization Regulation Of Transport Positive Regulation Of Phagocytosis Host-mediated Perturbation Of Viral Process Negative Regulation Of Viral Process Microtubule Organizing Center Organization Apical Part Of Cell Identical Protein Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Phagocytosis Host-mediated Perturbation Of Symbiont Process
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