PTPRR and LMTK2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PTPRR	LMTK2
Description		protein tyrosine phosphatase receptor type R	lemur tyrosine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm	Cytoplasm Early Endosome Golgi Apparatus Endomembrane System Membrane Growth Cone Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin VI Binding Protein Serine Kinase Activity
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Signal Transduction Negative Regulation Of Epithelial Cell Migration ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion	Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) HDL cholesterol levels ( 32203549) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)	Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		28 interacting genes: AATK CNKSR1 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR IRS2 KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK SNCA TEK	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		5801	22853
HPRD ID		04169	13994
Ensembl ID		ENSG00000153233	ENSG00000164715
Uniprot IDs		B7Z998 Q15256	Q8IWU2
PDB IDs		2A8B
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Autophosphorylation ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Coreceptor Activity Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Animal Organ Development Epidermal Growth Factor Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Multicellular Organismal Process Membrane	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Dephosphorylation Hydrolase Activity Cation Binding Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Modification Process Glycogen Metabolic Process Cytoplasm Negative Regulation Of MAPK Cascade Peptidyl-tyrosine Dephosphorylation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Kinase 5 Complex Photoperiodism Entrainment Of Circadian Clock Cytosol MAPK Cascade Rhythmic Process Cell Division Protein Kinase Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Nucleoplasm Protein Metabolic Process Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Activity Layer Formation In Cerebral Cortex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Protein Phosphatase 1 Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Signaling Regulation Of Establishment Of Protein Localization
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