PTPRB and CNTNAP1

Number of citations of the paper that reports this interaction (PubMedID 9118959)
42

Data Source:
HPRD (in vivo)

		PTPRB	CNTNAP1
Description		protein tyrosine phosphatase receptor type B	contactin associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane	Membrane Paranodal Junction Paranode Region Of Axon Anchoring Junction Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding	Protein Binding SH3 Domain Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Osteoblast Differentiation Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Glial Cell Migration Dephosphorylation Developmental Process Negative Regulation Of Osteoblast Differentiation	Protein Localization To Paranode Region Of Axon Mitochondrion Organization Cytoskeleton Organization Cell Adhesion Signal Transduction Axonogenesis Central Nervous System Development Neuronal Action Potential Propagation Central Nervous System Myelination Myelination In Peripheral Nervous System Paranodal Junction Assembly Neuron Projection Development Myelination Neuron Projection Morphogenesis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuromuscular Process Protein Localization To Juxtaparanode Region Of Axon Regulation Of Synapse Maturation Postsynaptic Density Organization Neuromuscular Junction Development, Skeletal Muscle Fiber Paranodal Junction Maintenance
Pathways		Neutrophil degranulation	Neurofascin interactions
Drugs		{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Breast cancer ( 29059683) Major depressive disorder ( 27777418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: CDH5 CNTN1 CNTNAP1 CTNNB1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC	9 interacting genes: CCR4 FYN LCOR NFASC PTPRB RBM11 RHOA RTN4 SRC
Entrez ID		5787	8506
HPRD ID		01474	03825
Ensembl ID		ENSG00000127329	ENSG00000108797
Uniprot IDs		F8VU56 P23467 Q86VA4	P78357
PDB IDs		2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X 8JBN 8JBY
Enriched GO Terms of Interacting Partners?		Cell Adhesion Protein Phosphatase Binding Regulation Of Cellular Component Organization Cell-cell Junction Anchoring Junction Cell Junction Cell-cell Adhesion Bicellular Tight Junction Cell-cell Adhesion Mediator Activity Regulation Of Endothelial Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Mechanical Stimulus Receptor Complex Cell Junction Organization Basal Plasma Membrane Developmental Process Animal Organ Development Membrane Anatomical Structure Morphogenesis Synapse Organization Cell Junction Assembly Glutamatergic Synapse Action Potential Propagation Neuronal Action Potential Propagation Regulation Of Rho Protein Signal Transduction Endothelial Cell Morphogenesis Regulation Of Developmental Process Cell Surface Cadherin Binding Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activator Activity Response To Estradiol Morphogenesis Of An Epithelium Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Cell-cell Junction Assembly Protein Localization To Cell-cell Junction Positive Regulation Of Homotypic Cell-cell Adhesion Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Tissue Morphogenesis Regulation Of Establishment Or Maintenance Of Cell Polarity Anatomical Structure Formation Involved In Morphogenesis	Cell Migration Cell Motility Positive Regulation Of Podosome Assembly Phospholipase Activator Activity Regulation Of Podosome Assembly Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Neuron Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Phospholipase Binding Cellular Response To Lectin Ephrin Receptor Binding Glial Cell Migration Cerebral Cortex Cell Migration Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Junction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Telencephalon Cell Migration Regulation Of Cell Projection Organization Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Reactive Oxygen Species Biosynthetic Process T Cell Costimulation Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Junction Assembly Positive Regulation Of T Cell Activation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Peptidyl-tyrosine Phosphorylation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synapse Organization Negative Regulation Of Cell-substrate Adhesion Cell Differentiation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Ficolin-1-rich Granule Membrane Actin Filament Bundle Organization Actin Filament Bundle Assembly
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