LSM2 and SMN1

Number of citations of the paper that reports this interaction (PubMedID 10851237)
0

Data Source:
HPRD (in vitro)

		LSM2	SMN1
Description		LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	survival of motor neuron 1, telomeric
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding Small GTPase Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)
Interacting Genes		39 interacting genes: BANP CBX8 CEBPA CRMP1 DNAAF11 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LGALS7 LGALS7B LNX1 LSM1 LSM12 LSM3 LSM5 LSM6 LSM7 LSM8 LZTS1 MAGEA3 MAGEA6 MEOX2 PATL1 PCM1 PNMA1 RALA REL RSRC1 SF3B2 SMN1 SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408	166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		57819	6606
HPRD ID		06282	02646
Ensembl ID		ENSG00000204392	ENSG00000172062
Uniprot IDs		Q9Y333	B4DP61 E7EQZ4 Q16637
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Lsm2-8 Complex U4/U6 X U5 Tri-snRNP Complex U6 SnRNP Lsm1-7-Pat1 Complex RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome Precatalytic Spliceosome MRNA Processing Spliceosomal Complex RNA Processing U12-type Spliceosomal Complex MRNA Catabolic Process RNA Metabolic Process Catalytic Step 2 Spliceosome Ribonucleoprotein Complex RNA Binding Spliceosomal Complex Assembly RNA Catabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process P-body PICln-Sm Protein Complex Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Spliceosomal SnRNP Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP Methylosome Nuclear Speck Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA U6 SnRNA Binding Histone MRNA Catabolic Process P-body Assembly Negative Regulation Of Metabolic Process MRNA Methylguanosine-cap Decapping Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression U1 SnRNP U5 SnRNP RNA Decapping Protein Binding	Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding
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