PTPN4 and ZZEF1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTPN4	ZZEF1
Description		protein tyrosine phosphatase non-receptor type 4	zinc finger ZZ-type and EF-hand domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Glutamate Receptor Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels
Drugs		Alendronic acid
Diseases
GWAS		Lymphocyte count ( 32888494)	Anti-saccade response ( 29064472) Diastolic blood pressure ( 27841878) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 34099189) Type 2 diabetes ( 28566273 29632382 30054458 30297969 30718926) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		13 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 VANGL2 ZZEF1	4 interacting genes: HSPB3 PHYHIP PTPN4 SKIL
Entrez ID		5775	23140
HPRD ID		01471	15906
Ensembl ID		ENSG00000088179	ENSG00000074755
Uniprot IDs		P29074	O43149
PDB IDs		2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0 7VZE
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Protein Localization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Metal Ion Binding Post-embryonic Forelimb Morphogenesis Chromosome, Subtelomeric Region Signal Transduction In Response To DNA Damage Regulation Of Organelle Organization Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Scaffold Protein Binding Response To Cholecystokinin Translational Elongation Translation Elongation Factor Activity Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Excitatory Postsynaptic Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Triglyceride Metabolic Process Thymidine Kinase Activity Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Cerebellar Neuron Development Directional Locomotion Acylglycerol Metabolic Process Neutral Lipid Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Protein Localization To Chromosome Signal Transduction By P53 Class Mediator Cellular Developmental Process Positive Regulation Of Chromosome Organization Kinase Binding
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