WDFY4 and PTPN20

		WDFY4	PTPN20
Description		WDFY family member 4	protein tyrosine phosphatase non-receptor type 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Hydrolase Activity
	Biological Process	Autophagy Antigen Processing And Presentation CD8-positive, Alpha-beta T Cell Activation Cellular Response To Virus	Lymphangiogenesis
Pathways			Interleukin-37 signaling
Drugs
Diseases
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Clinically amyopathic dermatomyositis ( 29331962) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rheumatoid arthritis ( 24390342 30423114 30891314) Stroke ( 26089329) Systemic lupus erythematosus ( 19838193 20169177 23273568 26502338 26606652 26663301 27399966 28714469 33272962)
Interacting Genes		2 interacting genes: GPRIN2 PTPN20	9 interacting genes: AATK ARHGAP22 EGFR ERBB3 ERBB4 KIT MAPK8 ROR2 WDFY4
Entrez ID		57705	26095
HPRD ID		19624	10898
Ensembl ID		ENSG00000128815	ENSG00000204179
Uniprot IDs		A0A1W7HCV9 Q6ZS81	Q4JDK3 Q4JDL3
PDB IDs
Enriched GO Terms of Interacting Partners?		Lymphangiogenesis	Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex ERBB2 Signaling Pathway ATP Binding Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Basolateral Plasma Membrane Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Growth Factor Binding Positive Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Peptidyl-tyrosine Phosphorylation Animal Organ Development Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Response To Light Stimulus Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction JUN Phosphorylation Clathrin-coated Endocytic Vesicle Membrane
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