USP28 and UCHL3

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP28	UCHL3
Description		ubiquitin specific peptidase 28	ubiquitin C-terminal hydrolase L3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Binding Deubiquitinase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Proteolysis DNA Damage Response Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification
Pathways		Ub-specific processing proteases	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		43 interacting genes: ATXN3L BAP1 CDC73 CFTR CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 TTC3 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	24 interacting genes: ATM ATXN7L3 CCNB1 CDH1 CEBPA FOXM1 LONRF1 NEDD8 NSG2 PJA1 PKD2 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5 YAP1
Entrez ID		57646	7347
HPRD ID		15632	04367
Ensembl ID		ENSG00000048028	ENSG00000118939
Uniprot IDs		A0A8V8TLZ9 B4E3L3 Q96RU2	A0A140VJZ4 P15374
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK 7TUO 8HJE 8P14 8P19 8P1P 8P1Q	1UCH 1XD3 6ISU 6QML 7YV4
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Post-translational Protein Modification Protein Modification Process Peptidase Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Protein K48-linked Deubiquitination Cysteine-type Endopeptidase Activity Deubiquitinase Activity Hydrolase Activity DeNEDDylase Activity Protein K63-linked Deubiquitination Ubiquitin Binding Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process P53 Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Catabolic Process Cytosol Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of TOR Signaling Protein Ubiquitination Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis DNA Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin Protein Ligase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Cellular Response To Gamma Radiation Post-translational Protein Modification Response To Gamma Radiation Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Protein K63-linked Ubiquitination Cellular Response To Ionizing Radiation Protein Ubiquitination Response To Stress Cellular Response To Camptothecin Regulation Of Primary Metabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Ubiquitin Protein Ligase Activity Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lithium Ion Nucleoplasm Interleukin-6-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Lithium Ion Cysteine-type Deubiquitinase Activity Regulation Of DNA Repair Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Deubiquitination Telomere Maintenance Signal Transduction By P53 Class Mediator Response To Toxic Substance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Organization Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Gland Development Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Deubiquitinase Activity Protein Polyubiquitination Protein Modification By Small Protein Removal DNA Damage Response
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