IFT80 and PLXNA2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		IFT80	PLXNA2
Description		intraflagellar transport 80	plexin A2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Ciliary Tip 9+0 Non-motile Cilium	Semaphorin Receptor Complex Plasma Membrane Membrane
	Molecular Function		Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Apoptotic Process Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Canonical NF-kappaB Signal Transduction Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Tissue Development Gene Expression Proteasomal Protein Catabolic Process Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Spinal Cord Development Osteoclast Differentiation Osteoblast Proliferation Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Intraciliary Anterograde Transport Odontogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Tooth Eruption Cilium Organization Stem Cell Differentiation Protein Stabilization Cartilage Development Limb Development Cilium Assembly Bone Development Bone Morphogenesis Articular Cartilage Development Odontoblast Differentiation Stem Cell Proliferation Receptor Localization To Non-motile Cilium Response To Inositol Non-motile Cilium Assembly Cartilage Homeostasis Negative Regulation Of Non-canonical Wnt Signaling Pathway	Somitogenesis Cell Surface Receptor Signaling Pathway Nervous System Development Synapse Assembly Anatomical Structure Morphogenesis Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Tube Development Animal Organ Development Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway
Pathways		Intraflagellar transport Intraflagellar transport	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Malaria ( 31844061)	Adolescent idiopathic scoliosis ( 31417091) Bitter alcoholic beverage consumption ( 31046077) Cardiac hypertrophy ( 21348951) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) General risk tolerance (MTAG) ( 30643258) Lung cancer in never smokers ( 28604730) Manganese levels ( 26025379) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		7 interacting genes: FGFR4 NMD3 OTOL1 PLXNA2 SLITRK3 UBXN10 ZBBX	6 interacting genes: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L
Entrez ID		57560	5362
HPRD ID		13853	03033
Ensembl ID		ENSG00000068885	ENSG00000076356
Uniprot IDs		Q9P2H3	O75051
PDB IDs			3Q3J
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Stress Granule Assembly Regulation Of Stress Granule Assembly Membraneless Organelle Assembly Organelle Assembly Macromolecule Catabolic Process Hyaluronan Biosynthetic Process Hyalurononglucosaminidase Activity Clathrin Heavy Chain Binding Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ER Retention Sequence Binding Nuclear Membrane Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Positive Regulation Of Male Gonad Development U3 SnoRNA Binding Hyaluronan Catabolic Process
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