LRRC7 and VANGL2

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid)

		LRRC7	VANGL2
Description		leucine rich repeat containing 7	VANGL planar cell polarity protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Adherens Junction Postsynaptic Density Basolateral Plasma Membrane Specific Granule Lumen Axon Initial Segment Synapse Postsynaptic Membrane	Stress Fiber Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole Cell Periphery Apical Cytoplasm Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Positive Regulation Of Neuron Projection Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Cochlea Development Cochlea Morphogenesis Regulation Of Establishment Of Planar Polarity Establishment Of Planar Polarity Involved In Neural Tube Closure Non-motile Cilium Assembly Regulation Of Synapse Pruning
Pathways			PCP/CE pathway Asymmetric localization of PCP proteins RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 21784300) Body mass index ( 24348519) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666) Psoriasis ( 25939698) Type 2 diabetes ( 31049640)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 24076602 31604244) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)
Interacting Genes		18 interacting genes: ACTN2 ACTN4 ADGRB1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 EPS15L1 ERBB2 ERBB3 ERBB4 HOMER3 HOMEZ NQO2 PPP1R9B TOR1A VANGL2	27 interacting genes: AP1M1 ARFRP1 ARHGEF12 DLG2 DLG4 DVL1 GIPC1 KBTBD7 LIN7A LRRC7 MAGI2 MAGI3 MAST1 MAST2 MPDZ PDZRN3 PTPN13 PTPN4 SCRIB SNTA1 SNTB1 SNTG1 SNTG2 SNX27 SQSTM1 SYNJ2BP VCP
Entrez ID		57554	57216
HPRD ID		09930	02758
Ensembl ID		ENSG00000033122	ENSG00000162738
Uniprot IDs		A0A075B6E9 A0A494C1A4 B1AKT2	A8K4L6 Q9ULK5
PDB IDs			6XA6 6XA7 6XA8 7R2M 7R2T 9JK7 9JKA
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Cortical Actin Cytoskeleton Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Protein Localization To Cell Periphery Regulation Of Protein Localization Peripheral Nervous System Development ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Basolateral Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Cellular Localization Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Dendritic Spine Glutamatergic Synapse Cellular Response To Epidermal Growth Factor Stimulus Cell Projection Response To Epidermal Growth Factor Regulation Of Metal Ion Transport Intracellular Protein Localization Synapse Regulation Of Protein Localization To Membrane ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Anchoring Junction Postsynaptic Actin Cytoskeleton Cell Junction Regulation Of Monoatomic Ion Transport Plasma Membrane Wound Healing Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Organization Cell Junction Organization Dendrite Regulation Of Transport Neuron Projection Development Synapse Organization Pseudopodium Postsynaptic Density Membrane Schwann Cell Development	Receptor Clustering Synapse Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Density Establishment Of Protein Localization Protein Localization To Membrane Localization Within Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Intracellular Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Endosomal Transport Establishment Or Maintenance Of Cell Polarity Intracellular Protein Localization Vesicle-mediated Transport Neuromuscular Junction Beta-1 Adrenergic Receptor Binding PDZ Domain Binding Cellular Localization Protein Localization To Cell Junction Neuron Projection Ionotropic Glutamate Receptor Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cytoplasm Glutamatergic Synapse Neuroligin Family Protein Binding Protein Transport Anchoring Junction Bicellular Tight Junction Vesicle-mediated Transport To The Plasma Membrane Protein Kinase Binding Establishment Of Localization In Cell Positive Regulation Of Neuron Projection Arborization GMP Kinase Activity Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization Ubiquitin-modified Protein Reader Activity Neurotransmitter Receptor Transport To Postsynaptic Membrane GDP Metabolic Process Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Juxtaparanode Region Of Axon Protein-containing Complex Localization Structural Molecule Activity
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