PTH1R and PTH

Number of citations of the paper that reports this interaction (PubMedID 9108031)
41

Data Source:
HPRD (in vivo)

		PTH1R	PTH
Description		parathyroid hormone 1 receptor	parathyroid hormone
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Skeletal System Development Ossification In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process	Skeletal System Development Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Bone Mineralization Positive Regulation Of Bone Mineralization Response To Nutrient Levels Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of D-glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Phosphate Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Abaloparatide Parathyroid hormone Teriparatide	D-norleucine ABX-PTH
Diseases		Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Birth weight ( 27680694 31043758) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 NHERF1 NHERF2 PTH PTHLH SMARCC1 STK16 TEKT4 UBC YWHAH	7 interacting genes: ASPH BAG6 FEZ1 MEP1A OS9 PTH1R PTH2R
Entrez ID		5745	5741
HPRD ID		01347	01345
Ensembl ID		ENSG00000160801	ENSG00000152266
Uniprot IDs		Q03431 Q0VGD7	P01270
PDB IDs		1BL1 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI 7UZO 7UZP 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7Y35 7Y36 8BIA 8BJ0 8D51 8D52 8FLQ 8FLR 8FLS 8FLT 8FLU 8GW8 8HA0 8HAF 8HAO 8JR9 9JR2 9JR3	1BWX 1ET1 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M 7VVK 7VVL 7VVM 7VVN 7VVO 7Y36 8FLQ 8HA0 8HAO 8T5F 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Hormone Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Phosphate Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Cartilage Development Protein-membrane Adaptor Activity Sensory Perception Molecular Adaptor Activity Semicircular Canal Formation Cyclic Purine Nucleotide Metabolic Process Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Glucocorticoid Catabolic Process Renal Phosphate Ion Absorption Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Regulation Of Chondrocyte Differentiation Phosphatase Binding Bone Mineralization Angiotensin Receptor Binding Abducens Nerve Formation Optokinetic Behavior Regulation Of Sodium Ion Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding	Parathyroid Hormone Receptor Activity Regulation Of Intracellular Transport Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Glycosylation-dependent Protein Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control ERAD Pathway Regulation Of Cellular Localization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity BAT3 Complex Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Maintenance Of Unfolded Protein Positive Regulation Of Proteolysis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Sarcoplasmic Reticulum Lumen Intracellular Calcium Ion Homeostasis Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Homeostasis Cortical Endoplasmic Reticulum Metallodipeptidase Activity Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Response To Endoplasmic Reticulum Stress Protein Targeting Protein Carrier Chaperone NK T Cell Activation Regulation Of Organelle Transport Along Microtubule Protein Retention In ER Lumen Negative Regulation Of Protein Exit From Endoplasmic Reticulum Hrd1p Ubiquitin Ligase Complex Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
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