PTAFR and SERINC5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PTAFR	SERINC5
Description		platelet activating factor receptor	serine incorporator 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Secretory Granule Membrane Tertiary Granule Membrane	Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Membrane Myelin Sheath Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity	L-serine Transmembrane Transporter Activity Phospholipid Scramblase Activity
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway	Immune System Process L-serine Biosynthetic Process Lipid Metabolic Process Phosphatidylserine Metabolic Process Phospholipid Biosynthetic Process L-serine Transport Plasma Membrane Phospholipid Scrambling Myelination Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling	Serine metabolism
Drugs		Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825)	Alzheimer's disease in APOE e4- carriers ( 25778476) Borderline personality disorder features ( 23979607) Fasting blood glucose ( 28371326) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SLC33A2 SPATA24 TMEM120A TMX2 TYK2	2 interacting genes: FXR1 PTAFR
Entrez ID		5724	256987
HPRD ID		01422	12828
Ensembl ID		ENSG00000169403	ENSG00000164300
Uniprot IDs		A8K7N8 P25105	Q86VE9
PDB IDs		5ZKP 5ZKQ 8XYD
Enriched GO Terms of Interacting Partners?		Myelin Sheath Compact Myelin G Protein-coupled Receptor Internalization Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Structural Constituent Of Myelin Sheath Myelination Axon Ensheathment Regulation Of Monoatomic Ion Transmembrane Transport Protein Heterooligomerization Positive Regulation Of Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Positive Regulation Of Excitatory Postsynaptic Potential Response To Interferon-beta Positive Regulation Of Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Substantia Nigra Development Regulation Of Monoatomic Ion Transport Terminal Bouton Propylene Metabolic Process Positive Regulation Of Metalloendopeptidase Activity Type 8 Metabotropic Glutamate Receptor Binding Response To Virus Regulation Of Membrane Potential Positive Regulation Of Receptor Signaling Pathway Via STAT Calmodulin Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Angiotensin Receptor Binding Positive Regulation Of Cell Communication Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Excitatory Postsynaptic Potential Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Glycine Response To Amyloid-beta Negative Regulation Of Glycine Import Across Plasma Membrane Type I Interferon-mediated Signaling Pathway Regulation Of Transcytosis TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Nervous System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Potassium Ion Transmembrane Transport	Platelet Activating Factor Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Activity Inositol Trisphosphate Metabolic Process Lipopolysaccharide Immune Receptor Activity RNA Strand Annealing Activity Nuclear Pore Localization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Membraneless Organelle Inositol Phosphate Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Nuclear Pore Complex Assembly Costamere Ribonucleoprotein Granule Nuclear Pore Organization Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Inositol Phosphate Metabolic Process Purinergic Nucleotide Receptor Signaling Pathway MRNA 3'-UTR AU-rich Region Binding Dentate Gyrus Development Regulation Of Circadian Sleep/wake Cycle Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Rho Protein Signal Transduction Cytoplasmic Translational Initiation Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Ribonucleoprotein Complex Binding Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Molecular Condensate Scaffold Activity Regulation Of Neuronal Synaptic Plasticity Tertiary Granule Membrane Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein-containing Complex Localization Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of MRNA Catabolic Process Regulation Of Behavior Translational Initiation Cytoplasmic Ribonucleoprotein Granule Regulation Of Rho Protein Signal Transduction
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