GFOD3P and PLCH2

		GFOD3P	PLCH2
Description		Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogene	phospholipase C eta 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Plasma Membrane Membrane
	Molecular Function		Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process		Lipid Metabolic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol
Pathways			Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS			Body mass index ( 26426971) Irritable mood ( 29500382) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Ulcerative colitis ( 21297633 23128233)
Interacting Genes		2 interacting genes: CFTR PLCH2	7 interacting genes: AGTR1 CAMTA1 CEP104 GFOD3P HRAS PEX10 TNKS
Entrez ID		57212	9651
HPRD ID		13803	18986
Ensembl ID		ENSG00000293478	ENSG00000149527
Uniprot IDs			O75038
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Inorganic Ion Transmembrane Transport Golgi-associated Vesicle Membrane Phospholipase C Activity Cellular Response To Forskolin Monoatomic Ion Transmembrane Transport Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Monoatomic Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phosphatidylinositol-mediated Signaling Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Lipid Metabolic Process Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transmembrane Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Phosphoric Diester Hydrolase Activity Cellular Response To CAMP Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol
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