PSME1 and TUBB4B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSME1	TUBB4B
Description		proteasome activator subunit 1	tubulin beta 4B class IVb
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Azurophil Granule Lumen Sperm Flagellum Cell Projection Intercellular Bridge Extracellular Exosome Mitotic Spindle Extracellular Vesicle
	Molecular Function	Protein Binding Endopeptidase Activator Activity	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Antigen Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Flagellated Sperm Motility Natural Killer Cell Mediated Cytotoxicity
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Copper	Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases
GWAS
Interacting Genes		24 interacting genes: AIMP2 AP1B1 APP ATP1B1 CDC37 CEBPA CHD3 EIF6 EMD EMG1 FXR1 FXR2 PFDN1 PIK3R3 PSME2 RPP14 SETDB1 SMN1 TK1 TTC3 TUBB4B USP22 VCL VIM	27 interacting genes: ACD CDKN2A CEBPA DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 NEDD8 NELFB OGT POT1 PSME1 PTEN PTPRE RSPH1 SCG2 SOCS6 SOCS7 SPACA9 SUMO2 TERF1 TINF2 TSC1 TUBG1 WEE2-AS1
Entrez ID		5720	10383
HPRD ID		02803	04043
Ensembl ID		ENSG00000092010	ENSG00000188229
Uniprot IDs		A0A0K0K1L8 Q06323 Q86SZ9	P68371
PDB IDs		1AVO 7DR6 7DRW 7NAO 7NAP 8CXB	7UN1 7UNG 8J07 8SH7
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Neuron Projection Protein Heterodimerization Activity Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Post-transcriptional Regulation Of Gene Expression Cytoplasm Positive Regulation Of Gene Expression Costamere Cytoplasmic Ribonucleoprotein Granule Nucleolus Extracellular Vesicle Regulation Of Amyloid Fibril Formation Translation Regulator Activity Cytosol Unfolded Protein Binding Dentate Gyrus Development Positive Regulation Of Protein Metabolic Process Amyloid Fibril Formation Nucleus Positive Regulation Of Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding TMEM240-body Assembly Of Large Subunit Precursor Of Preribosome Positive Regulation Of Translation Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome RRNA (pseudouridine) Methyltransferase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Size Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Chromosome Organization Organelle Organization Protein Tag Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Body Organization DNA Biosynthetic Process SUMO Transferase Activity Nucleus Negative Regulation Of Metabolic Process Meiotic Spindle Organization Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Component Organization
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