BAD and S100A10

Number of citations of the paper that reports this interaction (PubMedID 9369453)
0

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vivo, two hybrid)

		BAD	S100A10
Description		BCL2 associated agonist of cell death	S100 calcium binding protein A10
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane BAD-BCL-2 Complex	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Protein Kinase Binding Protein Phosphatase Binding Cysteine-type Endopeptidase Activator Activity	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Transmembrane Transporter Binding Calcium-dependent Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Type B Pancreatic Cell Proliferation Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development	Membrane Raft Assembly Vesicle Budding From Membrane Positive Regulation Of Plasminogen Activation MRNA Transcription By RNA Polymerase II Positive Regulation Of GTPase Activity Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Plasma Membrane Repair
Pathways		Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	Dissolution of Fibrin Clot
Drugs		Navitoclax	Phenethyl Isothiocyanate
Diseases
GWAS		Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 31619474) Diverticular disease ( 30177863) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		47 interacting genes: ACTN2 AKT1 ARAF BBS1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CHEK1 CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	23 interacting genes: ANXA2 ANXA7 BAD CBR3 CDK16 COPS6 CTSB DSCAM ERBB3 FSHR KCNK3 MLKL NANOS2 PLA2G4C PLG S100A3 S100Z SETDB1 SUMO2 TRPV5 TRPV6 USP2 ZGPAT
Entrez ID		572	6281
HPRD ID		04409	00232
Ensembl ID		ENSG00000002330	ENSG00000197747
Uniprot IDs		Q92934	P60903
PDB IDs		1G5J 7Q16	1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Cytosol Apoptotic Process Programmed Cell Death Cell Death Protein Phosphorylation Response To Stress TORC1 Signaling Regulation Of Cellular Component Organization Signal Transduction Phosphorylation Protein Sequestering Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cytoplasm Cellular Response To Starvation TOR Signaling Cellular Response To Nutrient Levels Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification Process Response To Starvation Protein Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Phosphoserine Residue Binding Extrinsic Apoptotic Signaling Pathway Channel Activity Positive Regulation Of Programmed Cell Death Mitochondrial Outer Membrane Intracellular Signaling Cassette Bcl-2 Family Protein Complex Regulation Of Protein Localization Identical Protein Binding ATP Binding Intracellular Protein Localization Apoptotic Signaling Pathway	Calcium-dependent Protein Binding Calcium-dependent Phospholipid Binding Plasma Membrane S100 Protein Binding
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