MCOLN1 and SLC35E1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCOLN1	SLC35E1
Description		mucolipin TRP cation channel 1	solute carrier family 35 member E1
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Cell Projection Receptor Complex	Golgi Apparatus Membrane
	Molecular Function	Monoatomic Anion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Iron Ion Transmembrane Transporter Activity Protein Binding Lipid Binding Identical Protein Binding NAADP-sensitive Calcium-release Channel Activity Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Ligand-gated Calcium Channel Activity	Protein Binding Antiporter Activity
	Biological Process	Adaptive Immune Response Immune System Process Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Lysosome Organization Calcium-mediated Signaling Transferrin Transport Monoatomic Ion Transmembrane Transport Iron Ion Transmembrane Transport Sodium Ion Transmembrane Transport Negative Regulation Of Innate Immune Response Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To PH Potassium Ion Transmembrane Transport Phagosome Maturation Autophagosome Maturation Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Calcium Ion Export Positive Regulation Of Lysosome Organization	Transmembrane Transport
Pathways		TRP channels Transferrin endocytosis and recycling
Drugs
Diseases		Mucolipidosis IV
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean platelet volume ( 32888494) Opioid overdose severity score ( 31362332)
Interacting Genes		5 interacting genes: APPBP2 GPR35 SEC22A SLC35E1 TRIM27	7 interacting genes: ABCF3 COLGALT1 FTHL17 FXYD6 LAMA3 MCOLN1 MPP1
Entrez ID		57192	79939
HPRD ID		05582	15373
Ensembl ID		ENSG00000090674	ENSG00000127526
Uniprot IDs		Q9GZU1	Q96K37
PDB IDs		5TJA 5TJB 5TJC 5WJ5 5WJ9 6E7P 6E7Y 6E7Z 7MGL
Enriched GO Terms of Interacting Partners?			Laminin-5 Complex Hemidesmosome Assembly Hemidesmosome Laminin-3 Complex Monoatomic Cation Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Potassium Ion Transport Metal Ion Transport Sodium Ion Transport Ion Channel Regulator Activity Iron Ion Transport Ferric Iron Binding Positive Regulation Of Lysosome Organization Monoatomic Anion Channel Activity Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Calcium Ion Export Ligand-gated Calcium Channel Activity NAADP-sensitive Calcium-release Channel Activity Iron Ion Transmembrane Transporter Activity Procollagen Galactosyltransferase Activity Positive Regulation Of Collagen Fibril Organization GMP Kinase Activity Regulation Of Collagen Fibril Organization GDP Metabolic Process Monoatomic Ion Transport Transferrin Transport Phagosome Maturation
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