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PSMD11 and BRD7
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMD11
BRD7
Description
proteasome 26S subunit, non-ATPase 11
bromodomain containing 7
Image
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Protein-containing Complex
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Nuclear Matrix
RSC-type Complex
Molecular Function
Structural Molecule Activity
Protein Binding
Transcription Cis-regulatory Region Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Histone Binding
Histone H3K14ac Reader Activity
Histone Reader Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasome Assembly
Stem Cell Differentiation
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitotic Cell Cycle
Wnt Signaling Pathway
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myoblast Differentiation
Transcription Initiation-coupled Chromatin Remodeling
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Regulation Of G0 To G1 Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Double-strand Break Repair
Regulation Of Nucleotide-excision Repair
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Regulation of TP53 Activity through Acetylation
Formation of the polybromo-BAF (pBAF) complex
Drugs
Diseases
GWAS
Schizophrenia (
33169155
)
Allergic sensitization (
30013184
)
Epilepsy (
30531953
)
Liver enzyme levels (alanine transaminase) (
24124411
)
Medication use (thyroid preparations) (
31015401
)
Interacting Genes
38 interacting genes:
APP
BRD7
CCDC90B
CCSER2
CDC42
CEBPA
COPS2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRKAB2
PRKACA
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
30 interacting genes:
AGR2
BARD1
BHLHE40
BRD3
BTBD2
DVL1
FTH1
H2AC16
H2BC21
H3-3A
H3-4
H3C14
H4C16
HAP1
HNRNPUL1
IRF2
LAMA4
LRIF1
MX1
NEFL
PAFAH1B3
PARP1
PCBD1
PLEKHF2
PSMD11
PTPN13
RIF1
RPLP1
SERPINB9
TRIM24
Entrez ID
5717
29117
HPRD ID
05119
12531
Ensembl ID
ENSG00000108671
ENSG00000166164
Uniprot IDs
O00231
A0AA34QVS2
Q9NPI1
PDB IDs
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
2I7K
5MQ1
6PPA
6V0Q
6V16
6V17
6V1E
6V1F
6V1H
7VDV
7Y8R
Enriched GO Terms of Interacting Partners
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SMAD Protein Complex
Heteromeric SMAD Protein Complex
Transforming Growth Factor Beta Receptor Signaling Pathway
I-SMAD Binding
SMAD Protein Signal Transduction
Negative Regulation Of Macromolecule Biosynthetic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Embryonic Pattern Specification
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Metabolic Process
Cardiac Conduction System Development
Cell Surface Receptor Signaling Pathway
Transcription Regulator Complex
Protein-containing Complex
Intracellular Signaling Cassette
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
DEAD/H-box RNA Helicase Binding
Regulation Of MiRNA Transcription
Chromatin Binding
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity
Regulation Of MiRNA Metabolic Process
Nucleotide-activated Protein Kinase Complex
Positive Regulation Of Cell Differentiation
Ureteric Bud Development
Co-SMAD Binding
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Differentiation
Primary MiRNA Processing
Signal Transduction
Mesonephric Tubule Development
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Mesonephric Epithelium Development
Gastrulation
Homomeric SMAD Protein Complex
Nucleus
Response To Growth Factor
Protein Kinase Binding
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Gene Expression
Response To Glucose
Chromatin Remodeling
Chromatin Organization
Protein Heterodimerization Activity
Structural Constituent Of Chromatin
Nucleosome
Chromosome
Chromosome, Telomeric Region
Nucleosome Assembly
Nucleosome Organization
Protein-DNA Complex Assembly
Nucleus
Barr Body
Telomere Organization
Negative Regulation Of Metabolic Process
Protein Localization To Chromatin
Heterochromatin Formation
Subtelomeric Heterochromatin Formation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Nucleoplasm
Chromatin
Cellular Response To Estrogen Stimulus
Extracellular Exosome
Retrograde Axonal Transport
Protein Binding
Protein Localization To Chromosome
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
Negative Regulation Of MRNA 3'-end Processing
Epigenetic Regulation Of Gene Expression
Histone H3K9cr Reader Activity
Histone H3K27cr Reader Activity
Histone H3K18cr Reader Activity
Histone H3K23ac Reader Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Neurotrophin Production
Positive Regulation Of ERBB Signaling Pathway
Chromosome, Telomeric Repeat Region
Regulation Of Developmental Process
Growth Cone
Response To Mineralocorticoid
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