PELI1 and IKBKB

Number of citations of the paper that reports this interaction (PubMedID 21204785)
44

Data Source:
BioGRID (enzymatic study)

		PELI1	IKBKB
Description		pellino E3 ubiquitin protein ligase 1	inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Transferrin Receptor Binding
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cytokine Production DNA Repair DNA Damage Response Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TORC1 Signaling T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of T Cell Activation Positive Regulation Of B Cell Activation Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Protein Polyubiquitination Pattern Recognition Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Maturation Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly
Pathways		Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes
Drugs			Mesalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases
GWAS		Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)
Interacting Genes		33 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB EGFR GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK3 SQSTM1 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14 ZAP70	91 interacting genes: ACVR1 AKT1 AURKA BTRC CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 COPS5 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HMGCL HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH MYC NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR ROCK1 SAMHD1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB
Entrez ID		57162	3551
HPRD ID		17834	04462
Ensembl ID		ENSG00000197329	ENSG00000104365
Uniprot IDs		Q53T26 Q96FA3	A0A499FJS7 G3V105 O14920
PDB IDs		9IF9	3BRT 3BRV 4E3C 4KIK 8OMV
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction ATP Binding Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Nucleotide Binding Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cytosol Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Transferase Activity Interleukin-1-mediated Signaling Pathway Toll Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Polyubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Protein-containing Complex Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cell Surface Toll-like Receptor Signaling Pathway Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Toll-like Receptor Signaling Pathway Post-translational Protein Modification Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Protein Serine Kinase Activity Immune Response-activating Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Cellular Response To Hypoxia Nucleus	Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Signal Transduction Protein Modification Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Protein Serine/threonine Kinase Activity Response To Stress Intracellular Signaling Cassette Macromolecule Metabolic Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Enzyme Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Gene Expression Positive Regulation Of Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Protein Serine Kinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?