SCYL3 and LHX8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SCYL3	LHX8
Description		SCY1 like pseudokinase 3	LIM homeobox 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Lamellipodium Cell Projection	Chromatin Nucleus
	Molecular Function	Protein Binding ATP Binding Kinase Activity Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Inflammatory Response Intracellular Protein Localization Cell Migration Spinal Cord Motor Neuron Differentiation Neuron Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Forebrain Neuron Development Neuron Differentiation Response To Ethanol
Pathways
Drugs
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107)
Interacting Genes		7 interacting genes: EZR GABARAPL1 GABARAPL2 LHX8 SHANK3 TCAF1 TXN2	26 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24
Entrez ID		57147	431707
HPRD ID		07459	17275
Ensembl ID		ENSG00000000457	ENSG00000162624
Uniprot IDs		Q8IZE3	Q68G74
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding GABA Receptor Binding Organelle Assembly Beta-tubulin Binding Autophagosome Maturation Mitophagy Autophagosome Membrane Autophagy Of Mitochondrion ATPase Binding Autophagosome Terminal Web Assembly Positive Regulation Of Anion Channel Activity Autophagosome Organization Autophagosome Assembly Guanylate Kinase-associated Protein Clustering Protein Localization To Cell Cortex Intestinal D-glucose Absorption Positive Regulation Of Monoatomic Anion Transport Phospholipid Binding Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Protein-containing Complex Disassembly Intestinal Hexose Absorption Synaptic Receptor Adaptor Activity Membrane To Membrane Docking Regulation Of Microvillus Length Macroautophagy Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Vacuole Organization Cellular Response To Starvation Microvillus Assembly Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Microvillus Organization Regulation Of Cellular Component Size Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Establishment Of Centrosome Localization Microtubule Binding Regulation Of Cell Projection Size Negative Regulation Of P38MAPK Cascade Cortical Microtubule Organization Astral Microtubule Organization Response To Starvation Cellular Response To Nutrient Levels Tat Protein Binding Vocal Learning	NK T Cell Differentiation Nucleus Protein Tyrosine Kinase Binding Response To Endothelin Cellular Response To Endothelin RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cell Development Signaling Adaptor Activity Response To Yeast Epigenetic Programming In The Zygotic Pronuclei DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II
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