NAT14 and MLC1

		NAT14	MLC1
Description		N-acetyltransferase 14 (putative)	modulator of VRAC current 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Membrane	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Astrocyte End-foot
	Molecular Function	DNA Binding Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	DNA-templated Transcription Initiation Positive Regulation Of DNA-templated Transcription	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases			Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Acne (severe) ( 24927181) Body mass index (adult) ( 28430825) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		14 interacting genes: ADRB2 CCR4 F2RL1 GALP HTR2B ISOC2 JUN MARCO MLC1 MOV10L1 RABAC1 YAE1 ZNF581 ZNF628	9 interacting genes: DAPK2 IRF8 KDM1A MYLK NAT14 PRMT6 ROCK1 SNCA TPT1
Entrez ID		57106	23209
HPRD ID		10036	05800
Ensembl ID		ENSG00000090971	ENSG00000100427
Uniprot IDs		Q8WUY8	B7Z2T9 Q15049
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Modulation Of Process Of Another Organism Blood Vessel Diameter Maintenance G Protein-coupled Receptor Activity Regulation Of Tube Size G-protein Alpha-subunit Binding Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Vasodilation Smooth Muscle Contraction Positive Regulation Of Intracellular Signal Transduction Vascular Process In Circulatory System Beta2-adrenergic Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Leading Edge Cell Differentiation Behavioral Response To Starvation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Early Endosome Amyloid-beta Binding Beta-adrenergic Receptor Activity Circulatory System Process Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Cellular Response To Anisomycin Positive Regulation Of Endothelial Cell Proliferation	Regulation Of Synaptic Vesicle Recycling Bleb Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Smooth Muscle Contraction Phosphorylation Protein Phosphorylation Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Transferase Activity Regulation Of Endocytosis Rho-dependent Protein Serine/threonine Kinase Activity Regulation Of Amide Metabolic Process Negative Regulation Of Apoptotic Process Tau Protein Binding Negative Regulation Of Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Autophagy Negative Regulation Of Programmed Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ectoderm Development Regulation Of Apoptotic Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Eosinophil Chemotaxis Positive Regulation Of Eosinophil Migration Autophagosome Lumen Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Response To Type II Interferon Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Neuron Apoptotic Process Regulation Of Signal Transduction Mesenchymal Cell Differentiation Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy
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