CCDC47 and IRAK1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CCDC47	IRAK1
Description		coiled-coil domain containing 47	interleukin 1 receptor associated kinase 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Protein Folding Chaperone Complex Multi-pass Translocon Complex	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Ribosome Binding Protein Folding Chaperone	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Osteoblast Differentiation Protein Folding ER Overload Response Endoplasmic Reticulum Organization Post-embryonic Development Endoplasmic Reticulum Calcium Ion Homeostasis ERAD Pathway Protein Insertion Into ER Membrane Calcium Ion Homeostasis Multi-pass Transmembrane Protein Insertion Into ER Membrane	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways			PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs			Fostamatinib
Diseases
GWAS			Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)
Interacting Genes		9 interacting genes: IRAK1 IRF7 OGT PTEN RPL7A SARM1 STING1 TIRAP TOM1L1	62 interacting genes: AKT1 BCL10 BTK CCDC47 FADD GDI1 H3-4 HRAS HSP90AA1 IDS IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JADE2 JUN LDHD MAGEA2 MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NMRK2 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RAB31 RASSF2 RIPK2 RPF1 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 UBE2E3 USP20 YTHDC2
Entrez ID		57003	3654
HPRD ID		17041	02235
Ensembl ID		ENSG00000108588	ENSG00000184216
Uniprot IDs		Q96A33	D3YTB5 P51617
PDB IDs		6W6L	6BFN
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Interferon-beta Production Innate Immune Response Signaling Adaptor Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Immune Response-activating Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Cytosol Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Signal Transduction Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Immune Response Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Response To Stress Intracellular Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway Response To External Biotic Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication
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