TULP4 and MAD1L1

		TULP4	MAD1L1
Description		TUB like protein 4	mitotic arrest deficient 1 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
	Molecular Function		Protein Binding Identical Protein Binding Kinetochore Binding
	Biological Process	Protein Ubiquitination	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint
Pathways		Neddylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 28552196) Lipoprotein (a) levels ( 26377243 33730874) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149 27089180) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 28115744 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604732 23666239 28604728) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		3 interacting genes: DCC MAD1L1 NEDD4	78 interacting genes: AIMP2 ALOX5 AMOTL2 ANXA5 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CCND2 CDC37 CDK18 CHERP CHST12 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FSCN1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 HOXA10 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 NXPH1 PIBF1 PIN4 PML PPP1R18 PRKAR1B PSMA1 RNF8 RPA3 S100P SIN3A SIN3B SPATA18 SPATA2 STAM SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TTYH3 TUBGCP4 TULP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID		56995	8379
HPRD ID		18246	04065
Ensembl ID		ENSG00000130338	ENSG00000002822
Uniprot IDs		Q9NRJ4	Q9Y6D9
PDB IDs			1GO4 4DZO 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Dorsal/ventral Axon Guidance Regulation Of Dendrite Development Spinal Cord Ventral Commissure Morphogenesis Channel Inhibitor Activity Phosphothreonine Residue Binding Formation Of Structure Involved In A Symbiotic Process Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex MAD1 Complex Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Kinetochore Binding Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Sodium Channel Inhibitor Activity Neuron Projection Development Regulation Of Neuron Projection Development Negative Regulation Of Collateral Sprouting Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Nuclear Pore Nuclear Basket Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitotic Sister Chromatid Segregation Negative Regulation Of Sodium Ion Transport Regulation Of Metaphase Plate Congression Regulation Of Collateral Sprouting Negative Regulation Of Cellular Component Organization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Cell Projection Organization Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Proline-rich Region Binding Postsynaptic Cytosol Receptor Catabolic Process RNA Polymerase Binding Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Viral Budding Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport	Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity
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