PSMB10 and PSKH1

		PSMB10	PSKH1
Description		proteasome 20S subunit beta 10	protein serine kinase H1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Nuclear Speck
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Proteolysis Humoral Immune Response T Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Determination Of Left/right Symmetry Heart Development
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		Carfilzomib
Diseases
GWAS		Crohn's disease ( 22412388) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSKH1 PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN	6 interacting genes: CDC6 HPR PSMB10 RDH13 SNTA1 ST3GAL2
Entrez ID		5699	5681
HPRD ID		01465	01511
Ensembl ID		ENSG00000205220	ENSG00000159792
Uniprot IDs		P40306	P11801
PDB IDs		6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW 7AWE 7B12 9FSV
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Alpha-subunit Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spermatoproteasome Complex Proteasomal Protein Catabolic Process Threonine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome Core Complex, Beta-subunit Complex Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nucleus Macromolecule Catabolic Process Proteolysis Catabolic Process Extracellular Exosome Dendrite Regeneration Endopeptidase Activity Ossification Involved In Bone Remodeling Nuclear Speck
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