PSMB8 and ABCB1

Number of citations of the paper that reports this interaction (PubMedID 15488952)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		PSMB8	ABCB1
Description		proteasome 20S subunit beta 8	ATP binding cassette subfamily B member 1
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome External Side Of Apical Plasma Membrane
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Immune System Process Proteolysis Antigen Processing And Presentation Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Proteolysis Involved In Protein Catabolic Process	G2/M Transition Of Mitotic Cell Cycle Response To Hypoxia Placenta Development Xenobiotic Metabolic Process Lipid Transport Female Pregnancy Lactation Circadian Rhythm Response To Xenobiotic Stimulus Hormone Transport Response To Mycotoxin Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Response To Progesterone Response To Vitamin A Response To Vitamin D Response To Glucagon Maintenance Of Blood-brain Barrier Cellular Response To Mycotoxin Daunorubicin Transport Phospholipid Translocation Response To Cadmium Ion Terpenoid Transport Intestinal Absorption Transmembrane Transport Establishment Of Blood-brain Barrier Transepithelial Transport Cellular Response To External Biotic Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Alkaloid Cellular Response To Tumor Necrosis Factor Cellular Response To Estradiol Stimulus Cellular Hyperosmotic Salinity Response Response To Dexamethasone Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Response To Thyroxine Response To Alcohol Response To Antineoplastic Agent Ceramide Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Response To L-glutamate Protein Localization To Bicellular Tight Junction Response To Glycoside Negative Regulation Of Sensory Perception Of Pain Cellular Response To Nonylphenol Positive Regulation Of Establishment Of Sertoli Cell Barrier Regulation Of Intestinal Absorption Carboxylic Acid Transmembrane Transport Cellular Response To Borneol Cellular Response To L-glutamate Response To Codeine Response To Quercetin Response To Cyclosporin A Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier Establishment Of Blood-retinal Barrier Positive Regulation Of Response To Drug Regulation Of Chloride Transport
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Interferon alpha/beta signaling Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	Abacavir transmembrane transport ABC-family proteins mediated transport Atorvastatin ADME Prednisone ADME
Drugs		Carfilzomib	ATP Medroxyprogesterone acetate Verapamil Roxithromycin Fentanyl Voacamine Elacridar Tesmilifene FM-VP4 Zosuquidar Tariquidar Miltefosine Tocofersolan Hycanthone Concanamycin A Dexverapamil Emopamil Lomerizine Tetrandrine Dofequidar Dexniguldipine ONT-093 HM-30181 Desmethylsertraline Reversin 121 Azvudine
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) IgA nephropathy ( 25305756 32912934) Nephropathy ( 21399633)	Appendicular lean mass ( 33097823) Bone mineral density (spine) and age at menarche ( 26312577) Cerebral microbleeds ( 32913026) Gallbladder cancer ( 28274756) Liver enzyme levels (alanine transaminase) ( 33972514) Neurological blood protein biomarker levels ( 31320639) Persistent chemotherapy-induced alopecia in breast cancer ( 32756886)
Interacting Genes		23 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID NOTCH4 PFDN5 POLR2G POMP PSMB10 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12	14 interacting genes: BCCIP CAV1 CD4 CD44 FBXO21 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2 USP7
Entrez ID		5696	5243
HPRD ID		01515	01370
Ensembl ID		ENSG00000204264	ENSG00000085563
Uniprot IDs		P28062	A4D1D2 P08183
PDB IDs		5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B 7AWE 7B12	6C0V 6FN1 6FN4 6QEX 7A65 7A69 7A6C 7A6E 7A6F 7O9W 8Y6H 8Y6I 9CR8 9CTC 9CTF 9CTG
Enriched GO Terms of Interacting Partners?		Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex ABC-type Peptide Transporter Activity TAP1 Binding Cytosol To Endoplasmic Reticulum Transport ABC-type Transporter Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I RNA Polymerase III Assembly RNA Polymerase I Assembly Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Amide Transport Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Antigen Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Macropinocytic Cup Glucosamine 6-phosphate N-acetyltransferase Activity ATP Hydrolysis Activity	Cytokine-mediated Signaling Pathway Response To Nutrient Levels Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Intracellular Signal Transduction Cellular Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Potassium Ion Transport Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cortex Regulation Of DNA-binding Transcription Factor Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Cellular Localization Inward Rectifier Potassium Channel Inhibitor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Metabolic Process Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Cardioblast Proliferation Protein Localization To Astral Microtubule Regulation Of Protein Kinase Activity Protein Stabilization Maintenance Of Protein Location In Cell Establishment Of Spindle Localization Macromolecule Metabolic Process Regulation Of Signal Transduction
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