SMYD2 and HUNK

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SMYD2	HUNK
Description		SET and MYND domain containing 2	hormonally up-regulated Neu-associated kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm
	Molecular Function	RNA Polymerase II Complex Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Heart Development Negative Regulation Of Cell Population Proliferation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator	Signal Transduction Intracellular Signal Transduction
Pathways		PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Age at first sexual intercourse ( 34211149) Diverticular disease ( 30177863) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301)	Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)
Interacting Genes		8 interacting genes: BTF3L4 ESR1 H3C14 HSP90AA1 HUNK RB1 SNX11 TP53	93 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TMPRSS15 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793
Entrez ID		56950	30811
HPRD ID		15406	09410
Ensembl ID		ENSG00000143499	ENSG00000142149
Uniprot IDs		Q9NRG4	P57058
PDB IDs		3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5 4O6F 4WUY 4YND 5ARF 5ARG 5KJK 5KJL 5KJM 5KJN 5V3H 5WCG 6CBX 6CBY 6MON 6N3G 9CKC 9CKF 9CKG
Enriched GO Terms of Interacting Partners?		Disordered Domain Specific Binding Glial Cell Apoptotic Process Nitric-oxide Synthase Regulator Activity Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Negative Regulation Of Glial Cell Proliferation Transcription Regulator Complex Protein Localization To Organelle 14-3-3 Protein Binding Chromatin Remodeling Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fibroblast Proliferation Response To Antibiotic Regulation Of Chromosome Organization Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Apoptotic Process Transcription Coactivator Binding Response To Xenobiotic Stimulus Regulation Of Telomere Maintenance Via Telomere Lengthening Ubiquitin Protein Ligase Binding Regulation Of Nitric Oxide Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Chromatin Organization CTP Binding Chromosome Organization DATP Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Intracellular Protein Localization Response To Osmotic Stress Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Enzyme Binding Regulation Of DNA Biosynthetic Process Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of Fibroblast Proliferation	Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity
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